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PubMed News (NIH) 01/15/2020 23:00
Contributors : Siyuan Feng ; Guobao Tian Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing Organism : Mycolicibacterium smegmatis MC2 155. To understand how GreA may affect gene expression at the transcriptional level, we performed whole-transcriptome RNA-seq analyses.
PubMed News (NIH) 12/16/2019 23:00
Contributors : David Langlais ; Philippe Gros Series Type : Genome binding/occupancy profiling by high throughput sequencing Organism : Mus musculus. We used a genome-wide screen in N-ethyl-N-nitrosourea (ENU)-mutagenized mice to identify genes in which recessive loss-of-function mutations protect against pathological neuroinflammation.
PubMed News (NIH) 12/12/2019 23:00
Status Public on Dec 13, 2019 Title Mycobacterium tuberculosis is protected from NADPH oxidase and LC3-associated phagocytosis by the LCP protein CpsA Organism Mus musculus Experiment type Expression profiling by high throughput sequencing Summary Mycobacterium tuberculosis’success as a pathogen comes from itsability to ...
PubMed News (NIH) 11/08/2019 23:00
Contributors : Artem Grigorov ; Taiana Kondratieva ; Konstantin Majorov ; Tatyana Azhikina ; Alexander S Apt Series Type : Expression profiling by high throughput sequencing ; Non-coding RNA profiling by high throughput sequencing Organism : Mycobacterium tuberculosis. This study was conducted to descripe transcriptomic changes of M.tuberculosis during neutrophil infection.
PubMed News (NIH) 11/01/2019
Contributors : Jianping Xie ; Jingjing Niu Series Type : Expression profiling by high throughput sequencing Organism : Mycolicibacterium smegmatis MC2 155. ROS can damage cellular components and is a key player in many cellular signaling. Tuberculosis remains a major global public health concern largely due to the ability of its causative agent-Mycobacterium tuberculosis (Mtb) to subvert ROS toxicity. DNA methylation deficiency was previously shown to attenuate the Mtb virulence. But the role of DNA methyltransferase in Mycobacteria survival and the link with ROS are unknown. Mycobacterial protein Rv3204 is a DNA methyltransferase specific for N4-methylcytosine instead of N6-methyladenine (m6A) or 5-methylocytosine (m5C). The survival rate o.
PubMed News (NIH) 10/31/2019
Contributors : An Van den Bossche ; Hugo Varet ; Odile Sismeiro ; Rachel Legendre ; Jean-Yves Coppee ; Vanessa Mathys ; Pieter-Jan Ceyssens Series Type : Expression profiling by high throughput sequencing Organism : Mycobacterium tuberculosis. In this study, the transcriptional response of two Mycobacterium tuberculosis strains to a pressure of the recently approved delamanid is investigated.

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