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PubMed News (NIH) 10/29/2020
Contributors : Xiannian Zhang ; Linna Peng ; Yingying Guo ; Wenjia Guo ; Jiacheng Yao ; Mingming Shao ; Wenyi Fan ; Yamei Chen ; Qionghua Cui ; Yiyi Xi ; Yanxia Sun ; Xiangjie Niu ; Xuan Zhao ; Liping Chen ; Yuqian Wang ; Yachen liu ; Jianbin Wang ; Chen Wu ; Dongxin Lin Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. Esophageal squamous-cell carcinoma (ESCC), one of the most prevalent and lethal malignant disease, has a complex but unknown tumor ecosystem.
PubMed News (NIH) 10/28/2020
Contributor : Xu Siming Series Type : Non-coding RNA profiling by high throughput sequencing Organism : Homo sapiens. We analyzed the circRNA expression profile in 6 pairs of samples of OSCC and normal oral mucosa tissues. The results showed that among the 122 DE circRNAs, 109 circRNAs were up-regulated and 13 circRNAs were down-regulated. 8 out of 10 selected circRNAs were validated by qRT-PCR. GO and KEGG analysis indicated identified DE circRNAs might be involved in the progression of OSCC.
PubMed News (NIH) 10/27/2020
Contributors : Zhaojian Gong ; Wei Xiong ; Zhaoyang Zeng ; Panchun Li Series Type : Expression profiling by array ; Non-coding RNA profiling by array Organism : Homo sapiens. Chewing betel nut is an important risk factor for the carcinogenesis of tongue squamous cell carcinoma (TSCC), but the mechanism is still unknown.To screen the lncRNAs associated with betel nut chewing-induced TSCC and identify potential biomarkers for the TSCC, we collected 5 pairs of TSCC and paracancerous tissues and monitored the resultant lncRNA and mRNA expression profiles using an lncRNA microarray.
ClinicalTrials.gov 10/26/2020 08:15
Condition : Locally Advanced Esophageal Squamous Cell Carcinoma Interventions : Drug: Sintilimab; Drug: Chemotherapy; Radiation: Radiation Therapy Sponsors : Sichuan Cancer Hospital and Research Institute; General Hospital of Ningxia Medical University; First Affiliated Hospital Xi'an Jiaotong University; Affiliated Hospital of Southwest Medical University; Chongqing Three Gorges Central Hospital Recruiting.

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