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Equities.com 06/03/2020 17:04
Image: Five-day chart, S&P 500 Index. Source: Yahoo Finance. By Stan Choe and Damian J. Troise. Stocks bubbled even higher on Wednesday, vaulting Wall Street back to where it was just one week after it set its all-time high earlier this year, as optimism builds that the economy can climb out of its current hole relatively quickly. The S&P 500 rose 1.4% for its fourth straight gain as lockdowns loosen around the world and raise hopes for a coming economic recovery. Treasury yields also strengthened in a sign of improved confidence after reports suggested that while the U.S. economy is still getting pummeled, it may not be as bad as economists had feared. “It’s fairly clear to us that the economy clearly bottomed in late April and early May,” s.
Izvestiya (Russia) 06/03/2020 17:01
Застройщиков обяжут подключать жилые дома к интернету. Рабочая группа «Нормативное регулирование» при АНО «Цифровая экономика» одобрила проект постановления правительства, предполагающий, что до введения новостроек в эксплуатацию будет прокладываться не только телефония и ТВ, но и сети доступа к Всемирной паутине. С документом ознакомились «Известия».
Clinical Diabetes 06/03/2020 17:00
Maternal stress during pregnancy exposes fetuses to hyper glucocorticoids (GC), which increases the risk of metabolic dysfunctions in offspring. Despite of being a key tissue for maintaining metabolic health, the impacts of maternal excessive GC on fetal brown adipose tissue (BAT) development and its long-term thermogenesis and energy expenditure remain unexamined. To test, pregnant mice were administrated with dexamethasone (DEX), a synthetic GC, in the last trimester of gestation, when BAT development is the most active. DEX offspring had glucose, insulin resistance and adiposity, also displayed cold sensitivity following cold exposure. In BAT of DEX offspring, Ppargc1a expression was suppressed, together with reduced mitochondrial densit.
Clinical Diabetes 06/03/2020 17:00
A failure in self-tolerance leads to autoimmune destruction of pancreatic β-cells and type 1 diabetes (T1D). Low molecular weight dextran sulfate (DS) is a sulfated semi-synthetic polysaccharide with demonstrated cytoprotective and immunomodulatory properties in vitro . However, whether DS can protect pancreatic β-cells, reduce autoimmunity and ameliorate T1D is unknown. Here we report that DS, but not dextran, protects human β-cells against cytokine-mediated cytotoxicity in vitro . DS also protects mitochondrial function and glucose-stimulated insulin secretion and reduces chemokine expression in human islets in a pro-inflammatory environment. Interestingly, daily treatment with DS significantly reduces diabetes incidence in pre-diabetic n.

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