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Interactions of transmembrane receptors with their extracellular ligands are essential for cellular communication and signaling and are therefore a major focus in drug discovery programs. The transition from in vitro to live cell interaction studies, however, is typically a bottleneck in many drug discovery projects due to the challenge of obtaining atomic‐resolution information under near‐physiological conditions. Although NMR spectroscopy is ideally suited to overcome this limitation, several experimental impairments are still present. Here we propose the use of methylcellulose hydrogels to study extracellular proteins and their interactions with plasma membrane receptors. This approach reduces cell sedimentation, avoids membrane receptor.
SvD (Sweden) 11/13/2019 12:19
Manchester City-spelaren Bernardo Silva stängs av en match och får böta 50 000 pund, motsvarande 624 000 kronor, för en tweet som anses rasistisk. I tweeten som Silva publicerade jämförde han sin lagkamrat Benjamin Mendy med en svart tecknad karaktär, meddelar det engelska fotbollsförbundet, FA. Silva raderade inlägget 46 minuter senare varpå ha...
Packet Storm 11/13/2019 12:17
Ubuntu Security Notice 4186-2 - USN-4186-1 fixed vulnerabilities in the Linux kernel for Ubuntu 16.04 LTS. This update provides the corresponding updates for the Linux Hardware Enablement kernel from Ubuntu 16.04 LTS for Ubuntu 14.04 ESM. Stephan van Schaik, Alyssa Milburn, Sebastian.
PhoneArena 11/13/2019 12:14
Apple has been having a tough time in China since late last year but one new suggests the recently released iPhone 11 series may have finally stopped the brand’s long period of negative growth. The iPhone 11's early release saved Apple in China According to the data gathered by IDC’s Quarterly Mobile Phone Tracker, smartphone brands shipped a combined total of 98.9 million smartphones across the third quarter of 2019, down 3.6% from the 102.6 million units that were sold twelve months earlier. Apple, as expected, continued to trail behind the competition in fifth place.
Multichannel News 11/13/2019 12:13
The Harvesting American Cybersecurity Knowledge through Education (HACKED) Act passed the Senate Commerce Committee Wednesday (Nov. 13) with an amendment that would create a cybersecurity exchange program between government and industry. The bill, which is co-sponsored by the bipartisan ...
Analyst house Gartner, Inc. released its 2019 Critical Capabilities for Identity Governance and Administration report. This serves as a companion resource to their popular Magic Quadrant Report. Used in conjunction with the Magic Quadrant, the Critical Capabilities Report acts as a vital additional resource; indeed, it can assist buyers of identity governance and administration solutions […]. .

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