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Healio News 09/24/2020 16:44
Researchers detected anti-SARS-CoV-2 IgG antibodies in the blood samples of some pediatric patients prior to viral clearance, according to a study published in The Journal of Pediatrics. “What we have found is something different than other viruses. In patients with COVID-19, for a brief period of time, there are antibodies and the virus at the same time,” Burak Bahar, MD, director of laboratory informatics at Children’s National Hospital, told Healio. “This is important information because people think that, ‘OK, I have the antibodies. I won't spread the disease,’”
Healio News 09/24/2020 16:29
Pain and fatigue levels remain high among patients with ankylosing spondylitis despite apparent disease control with biologic therapies, such as TNF inhibitors, according to a global survey published in the Journal of Clinical Rheumatology. “Inflammatory back pain is a common complaint in AS patients and a component of the clinical criteria for the classification of AS, prevalent in up to 45% of AS patients,” Vibeke Strand, MD, of Stanford University, and colleagues wrote. “Fatigue, also common in AS patients, strongly correlates with pain and can be as difficult to manage,
Healio News 09/24/2020 16:00
The results of four randomized, double-masked, vehicle-controlled trials showed KPI-121 0.25% is safe and well tolerated with no unexpected treatment-related adverse events in patients with dry eye disease, according to a study. “The clinical development program for KPI-121 0.25%, which will be marketed as Eysuvis if approved, is the largest to date for a dry eye product. In over 2,800 patients across the four trials, KPI-121 0.25% administered up to 28 days appeared safe and well tolerated with no unexpected adverse events,” Kim Brazzell, PhD, chief medical officer for Kala.
Healio News 09/24/2020 15:51
Between 2014 and 2018, HIV diagnoses among men who have sex with men (MSM) decreased 2.3% per year overall in the United States, and MSM also experienced improvements in linkage to care and viral suppression, study findings in MMWR showed. Black, Hispanic/Latino and younger MSM — those aged 13 to 19 years — experienced more limited decrease in HIV diagnoses, researchers reported, although all ethnic and racial groups saw gains in linkage to care and viral suppression. The report was published ahead of National Gay Men’s HIV/AIDS Awareness Day, which is Sept. 27. “MSM.
Healio News 09/24/2020 15:05
Male sex, high income and self-employment are predictors of faster return to work after total joint arthroplasty, while having a physically demanding job and longer length of stay are linked with slower return to work, according to a study. Alexander J. Rondon, MD, MBA, and colleagues at Rothman Orthopaedic Institute prospectively studied 391 patients who underwent TJA (243 hips, 148 knees) at a single institution between June 2017 and December 2017. All patients completed a biweekly REDCAP survey, which reported on clinical, demographic and occupational data, for 12 weeks following their TJA.
Healio News 09/24/2020 14:50
After a peritoneal dialysis education program, the number of staff at a Veterans Affairs center who scored their knowledge level on the topic as “high” and “very high” increased, according to presented research. “Growth of the [peritoneal dialysis] PD program increases the need for a competent and confident staff to care for PD patients,” study author Chechamma George, RN, BSN, CNN, wrote. The research was presented at the American Nephrology Nurses Association. George distributed a needs assessment survey that asked staff at James J. Peters VA Medical Center.
Healio News 09/24/2020 14:45
Prenatal cannabis exposure may increase risk for psychopathology during middle childhood, according to results of a cross-sectional study published in JAMA Psychiatry. “Although the number of studies on the potential effects of prenatal cannabis exposure is increasing, there have still been relatively few investigations,” Sarah E. Paul, BA, of the department of psychological and brain sciences at Washington University in St. Louis, told Healio Psychiatry. “Further, there has been little consistency in the findings. Heterogeneity in study design, covariates, sample size and.
Healio News 09/24/2020 14:38
Philips announced that a mechanical thrombectomy system to remove blood clots from vessels within the peripheral arterial and venous systems has received 510(k) clearance from the FDA and is now available in the U.S. The single-use system (QuickClear) incorporates both an aspiration pump and catheter and can simplify the thrombectomy procedure workflow, according to a press release from the company.
Healio News 09/24/2020 14:35
Multivitamin and mineral supplementation may decrease the length and severity of illnesses such as respiratory infections in older adults, according to research published in Nutrients. Researchers conducted a two-armed, parallel, randomized double-blinded study at a single center in Oregon to evaluate the impact of a multivitamin and mineral (MVM) supplement (Redoxon VI, Bayer) on the immune function of adults aged 55 years and older. Participants were assigned to take a MVM supplement each day for 12 weeks or placebo. Three weeks before receiving treatment, participants were asked to restrict.
Healio News 09/24/2020 14:34
Treatment with gefapixant, a P2X3 receptor antagonist reduced cough frequency and cough-related quality of life in patients with refractory or unexplained chronic cough, according to results of two phase 3 trials. “The rationale for treating chronic cough with a P2X3 receptor antagonist settles on the theory that [adenosine triphosphate] contributes to cough hypersensitivity through activation of this receptor, which is expressed in airway sensory nerves thought to be important in cough,” Lorcan McGarvey, MD, consultant respiratory physician and clinical professor in the School of.
Healio News 09/24/2020 13:56
Scheduling a mental health outpatient appointment following psychiatric discharge increased the odds of successful transition from hospital to community-based care, according to study results published in Journal of Clinical Psychiatry. “People who receive inpatient care for a mental illness have much lower rates of following up with treaters in the community after discharge, which is alarming,” Thomas E. Smith, MD, of New York State Psychiatric Institute, told Healio Psychiatry. “We wanted to understand more about what types of routine discharge planning practices are.
Healio News 09/24/2020 13:51
Additional, extended treatment with mirikizumab helped produce a clinical response in patients with ulcerative colitis who initially did not respond to treatment, according to study results. William J. Sandborn, MD, of the University of California, San Diego, and colleagues wrote that the drug (Lilly) has previously shown clinical efficacy in phase 2 studies of psoriasis and Crohn’s disease. “Induction regimens evaluated in most clinical trials are no more than 12 weeks, and some patients, especially those less responsive to initial induction treatment, could potentially improve.
Healio News 09/24/2020 13:51
CMS announced that rates of vaccinations and primary and preventive services among the 40 million children enrolled in Medicaid and the Children’s Health Insurance Program “steeply declined” during first few months of the COVID-19 pandemic. The agency also said “the potential for increased outbreaks of infectious disease due to decreased vaccinations is real, and can result in decreased school attendance, decreased learning and increased childhood illness in general.” CMS analyzed claims data from pediatric enrollees in Medicaid and the Children’s Health.
Healio News 09/24/2020 13:11
No patients who received pembrolizumab with a CD19/CD22-directed chimeric antigen receptor T-cell therapy experienced high-grade cytokine release syndrome, according to phase 1 study findings presented during ESMO Virtual Congress 2020. Results of the ALEXANDER trial also showed clinically meaningful and durable responses to AUTO3 (Autolus Therapeutics) among the study population, which included patients with relapsed or refractory diffuse large B-cell lymphoma. Cytokine release syndrome (CRS) is a common treatment-related toxicity of CAR T-cell therapy that requires inpatient monitoring and,
Healio News 09/24/2020 13:02
The CDC disseminated information about hygienic contact lens practices through social media, newsletters and other digital channels as part of Contact Lens Health Week from Aug. 17 to 21. The events were primarily digital due to COVID-19, Sarah Collier, MPH, analytic epidemiologist, Division of Foodborne, Waterborne and Environmental Diseases, National Center for Emerging Zoonotic Infectious Diseases, CDC, told Primary Care Optometry News. Contact Lens Health Week messaging included testimonial videos from patients who Collier said, “suffered serious contact lens-related eye infections.
Healio News 09/24/2020 12:30
Interim results from a phase 3b clinical trial in Europe showed Roclanda was non-inferior to Ganfort, according to a press release. The Mercury 3 trial compared IOP reduction in patients with open-angle glaucoma or ocular hypertension. The randomized, masked study included about 430 patients who received study medication once daily each evening. The 90-day topline data showed that Roclanda (netarsudil 0.02% and latanoprost 0.005% ophthalmic solution, Aerie Pharmaceuticals), marketed as Rocklatan in the United States, met the overall study objective by demonstrating non-inferiority to Ganfort.
Healio News 09/24/2020 12:11
A meta-analysis of 31 randomized controlled trials of antihypertensive drugs compared with placebo or other BP-lowering medications found no association between any antihypertensive drugs and cancer outcomes. According to findings presented at the virtual European Society of Cardiology Congress, neither ACE inhibitors, angiotensin receptor blockers, beta-blockers, calcium channel blockers nor diuretics were associated with risk for any cancer, including breast, colorectal, lung, prostate and skin cancer. “Our study has addressed an ongoing controversy about whether antihypertensive.
Healio News 09/24/2020 11:41
The NIH recently award $12 million to RTI International, an independent, nonprofit research institute, to support outreach and engagement efforts in ethnic and racial minority communities disproportionately impacted by the COVID-19 pandemic. “Addressing health disparities affecting racial and ethnic minority populations has long been a priority for NIH,” NIH Director Francis S. Collins, MD, PhD, said in a press release. “The burden of the COVID-19 pandemic borne by diverse communities, especially those that include Blacks and Latinos, makes clear the urgent need for.
Healio News 09/24/2020 11:35
The addition of atezolizumab to paclitaxel failed to significantly prolong PFS for patients with PD-L1-positive metastatic triple-negative breast cancer, according to phase 3 study results presented during ESMO Virtual Congress 2020. “We have known for some years now that triple-negative breast cancer is a heterogenous disease entity and we are aware that the prognosis has not changed over the years. There remains a high unmet clinical need,” David W. Miles, MD, MB, BS, BSc, FRCP, professor and medical oncologist at Mount Vernon Cancer Centre in Northwood, U.K., said during his.
Healio News 09/24/2020 11:00
Men hospitalized with HF with preserved ejection fraction experienced elevated risk for 1-year all-cause mortality compared with women, researchers reported. Moreover, Black patients experienced better 1-year survival compared with white patients. According to findings published in the Journal of the American Heart Association, age, heart rate, worsening renal function and low hemoglobin were associated with increased mortality regardless of sex or race. However, higher BP was found to be protective among all subgroups while BMI was protective among men. “HFpEF represents a major unmet need.

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