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PubMed News (NIH) 05/31/2020
Contributors : Liu Yuan ; Zhu Zhou Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. A large-panel gene expression analysis was conducted to identify biomarkers associated with the effectiveness of adding palbociclib to letrozole Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors have demonstrated significant activity in estrogen receptor-positive/human epidermal growth factor receptor 2-negative (ER+/HER2-) advanced breast cancer.
PubMed News (NIH) 05/31/2020
Contributors : Sebastian Reichert ; Patrick Ebner ; Eve-Julie Bonetti ; Arif Luqman ; Mulugeta Nega ; Jacques Schrenzel ; Cathrin Spröer ; Boyke Bunk ; Jörg Overmann ; Peter Sass ; Patrice François ; Friedrich Götz Series Type : Expression profiling by array Organism : Staphylococcus aureus. In this study we addressed the question how a mevalonate (MVA)-auxotrophic Staphylococcus aureus ΔmvaS mutant can revert to prototrophy.
PubMed News (NIH) 05/31/2020
Contributors : Tomas Venit ; Piergiorgio Percipalle ; Chris Toseland ; Nizar Drou Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. During transcription, RNA Polymerase II (RNAPII) is spatially organised into clusters that correlate with transcription activity.
PubMed News (NIH) 05/31/2020
Contributors : Kumiko Nakada-Tsukui ; Konomi Marumo ; Tomoyoshi Nozaki Series Type : Expression profiling by high throughput sequencing Organism : Entamoeba histolytica. To know the role of lysosomal hydrolase receptors in virulecne of enteric protozoan parasite Entamoeba histolytica, eleven cysteine protease binding protein family (CPBF) proteins were specifically silenced and examined the effect on virulence-related phenotypes.
PubMed News (NIH) 05/31/2020
Contributors : Yejie Shi ; Jun Chen Series Type : Expression profiling by high throughput sequencing Organism : Mus musculus. Senescence-associated alterations in microglia may have profound impact on cerebral homeostasis and stroke outcomes. However, the lack of a transcriptome-wide comparison between young and aged microglia in the context of ischemia limits our understanding of aging-related mechanisms. Herein, we performed bulk RNA sequencing analysis of microglia purified from cerebral hemispheres of young adult (10-week-old) and aged (18-month-old) mice 5 days after distal middle cerebral artery occlusion or sham operation. Considerable transcriptional differences were observed between young and aged microglia in healthy brains, indica.
PubMed News (NIH) 05/31/2020
Contributor : Nehad M Alajez Series Type : Expression profiling by array Organism : Homo sapiens. We have employed whole genome microarray to identify changes in gene expression in MDA-MB-231 cells transfected with hsa-miR-205-5p and hsa-miR-214-3p compared to scrambled miRNA precursors at 72 hours after transfection.
PubMed News (NIH) 05/31/2020
Contributors : Theresa E León ; Tanya Rapoz-D’Silva ; Cosetta Bertoli ; Sunniyat Rahman ; Michael Magnussen ; Brian Philip ; Nadine Farah ; Simon E Richardson ; Sara Ahrabi ; Jose A Guerra-Assunção ; Rajeev Gupta ; Elisabeth Nacheva ; Javier Herrero ; David C Linch ; Stephen Henderson ; Robertus de Bruin ; Marc R Mansour Series Type : Genome binding/occupancy profiling by high throughput sequencing Organism : Homo sapiens. Loss-of-function mutations of EZH2, the enzymatic component of PRC2, have been associated with poor outcome and chemotherapy resistance in T-cell acute lymphoblastic leukemia (T-ALL).
PubMed News (NIH) 05/31/2020
Contributors : Gian L Vita ; M'Hammed Aguennouz ; Francesca Polito ; Rosaria Oteri ; Massimo Russo ; Luca Gentile ; Cristina Barbagallo ; Marco Ragusa ; Carmelo Rodolico ; Rosa M Di Giorgio ; Antonio Toscano ; Giuseppe Vita ; Anna Mazzeo Series Type : Non-coding RNA profiling by array Organism : Homo sapiens. Transthyretin variant amyloidosis (ATTRv) is a rare autosomal dominant disease characterized by the accumulation of amyloid in many organs, mostly causing a sensory-motor neuropathy, cardiomyopathy, and dysautonomia.
PubMed News (NIH) 05/31/2020
Contributors : Duncan Coleman ; Keiko Sugimoto Series Type : Expression profiling by high throughput sequencing Organism : Arabidopsis thaliana. Plants form callus and regenerate new organs when incubated on phytohormone-containing media. While accumulating evidence suggests that these regenerative processes are governed by transcriptional networks orchestrating stress responses and developmental transitions, it remains unknown if post-translational regulatory mechanisms are involved in this process. Here, we find that SIZ1, which encodes an E3 ligase catalyzing attachment of the SMALL UBIQUITIN-LIKE MODIFIER (SUMO) to proteins, regulates wound-induced signal transduction and organ regeneration. We show that loss-of-function mutants for SIZ1.
PubMed News (NIH) 05/31/2020
Contributors : Xiaoling Jiang ; Zhaowei Cai ; Zhilan Xiao ; Huazhen Liu ; Li Liu Series Type : Non-coding RNA profiling by high throughput sequencing ; Expression profiling by high throughput sequencing Organism : Mus musculus. In this study we performed a systematic analysis of the non-coding RNA (ncRNA) transcriptomes of the Down Syndrome (DS) developing hippocampus using the DS mouse model Dp16(1)Yey.
AsiaOne 05/31/2020
In addition to disputing misleading claims made by US President Donald Trump about mail-in ballots this week, Twitter has added fact-checking labels to thousands of other tweets since introducing the alerts earlier this month, mostly on posts about the coronavirus. The company does not expect to need additional staff for the undertaking, Twitter spokeswoman Liz Kelley said on Saturday.

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