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Different hematological abnormalities are commonly associated with pulmonary tuberculosis even though inconsistent results have been described.
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European Respiratory Journal 03/26/2020 04:39
Background. The World Health Organization (WHO) recommends tuberculosis (TB) preventive treatment for high-risk groups. Isoniazid preventive therapy (IPT) has been used globally for this purpose for many years, including in pregnancy. This review assessed current knowledge about the safety of IPT in pregnancy. Methods. We searched PubMed, Embase, CENTRAL, Global Health Library and HIV and TB-related conference abstracts, until May 15, 2019, for randomised controlled trials (RCTs) and non-randomised studies (NRS) where IPT was administered to pregnant women. Outcomes of interest were: 1) maternal outcomes, including permanent drug discontinuation due to adverse drug reactions, any grade 3 or 4 drug-related toxic effects, death from any cause a.
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PubMed News (NIH) 03/26/2020
Contributor : Shetty R DYAVAR Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. We report the application of next generation sequencing technology for high-throughput profiling of total RNA to determine the expression of all genes expressed in human primary hepatocytes derived from three healthy (drug/tobacco/alcohol free) volunteers in response to anti-tuberculosis antibiotics, including, rifampin, rifabutin and rifapentine through comparison with gene profiles of vehicle (methanol) treated and untreated cells.
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Scroll.in (India) 03/24/2020 06:00
These individuals are also at high risk of spreading the disease to their family and neighbours, with studies estimating that a person with untreated tuberculosis usually infects an additional five to 15 people.
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Lancet 03/20/2020 03:12
Tuberculosis takes the life of one in five children developing the disease.1 Data from the pre-chemotherapy era suggest very young children are at highest risk for tuberculosis after exposure, and highly susceptible to the most severe forms of the disease.2,3 As a result, tuberculosis control efforts among children in high-burden countries are focused on those below 5 years of age.2 One of the most important efforts is provision of tuberculosis preventive therapy after tuberculosis exposure, yet only one in four children below 5 years of age who might benefit from life-saving preventive therapy will receive it.
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The WHO consolidated guidelines on tuberculosis: tuberculosis preventive treatment provides a comprehensive set of recommendations for programmatic management of tuberculosis preventive treatment (PMTPT) geared towards the implementers of the WHO End TB Strategy and also for countries intent upon TB elimination (9).
FeedNavigator (EU) 03/12/2020 12:07
JCI Insight - BCG vaccination reduces the mortality of Mycobacterium tuberculosis–infected type 2 diabetes mellitus mice.
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