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PubMed News (NIH) 09/17/2019
Contributors : Takashi Sato ; Hideo Watanabe Series Type : Genome binding/occupancy profiling by high throughput sequencing Organism : Homo sapiens. Lineage-specific transcriptional regulators control differentiation states not only during normal development but also during cancer evolution.
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Moreover, the chemopreventive activity of ETD nanovector on mice skin cancer model was evaluated.
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ClinicalTrials.gov 09/16/2019 07:44
All participants must be at increased risk of non-melanoma skin cancer as evidenced by a history of prior squamous or basal cell skin cancer, ongoing or history of actinic keratoses, and the presence, at baseline, of at least eight actinic keratoses on the face, neck ...
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Medindia.com 09/14/2019 07:07
In the case of melanoma, which is a particularly aggressive form of skin cancer, established immunotherapies focus on T cells.
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News-Medical.net 09/13/2019 22:17
... research team led by dermatologists Johannes Griss and Stephan Wagner from MedUni Vienna's Department of Dermatology has now found that particular subtypes of these B-cells play an essential role in the immune response to melanoma.
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Environmental News Network 09/13/2019 10:58
In the case of melanoma, which is a particularly aggressive form of skin cancer, established immunotherapies focus on T cells.
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Purpose:. Uveal melanomas (UM) are genetically simple tumors carrying few copy number alterations (CNA) and a low mutation burden, except in rare MBD4 -deficient, hypermutated cases. The genomics of uveal melanoma metastatic progression has not been described. We assessed the genetic heterogeneity of primary and metastatic MBD4 -proficient and -deficient uveal melanomas. Experimental Design: We prospectively collected 75 metastatic and 16 primary samples from 25 consecutive uveal melanoma patients, and performed whole-exome sequencing. Results:. MBD4 -proficient uveal melanomas contained stable genomes at the nucleotide level, acquiring few new single nucleotide variants (SNVs; 16 vs. 13 in metastases and primary tumors, respectively), and no.
More from Clinical Cancer Research - Recent Issues (abstracts):
Tumor cell–derived extracellular vesicles (EV) convert normal myeloid cells into myeloid-derived suppressor cells (MDSC), inhibiting antitumor immune responses. Here, we show that EV from Ret mouse melanoma cells upregulate the expression of programmed cell death ligand 1 (PD-L1) on mouse immature myeloid cells (IMC), leading to suppression of T-cell activation. PD-L1 expression and the immunosuppressive potential of EV-generated MDSC were dependent on the expression of Toll-like receptors (TLR). IMC from Tlr4−/− mice failed to increase T-cell PD-L1 expression and immunosuppression with Ret-EV treatment, and this effect was dependent on heat-shock protein 86 (HSP86) as HSP86-deficient Ret cells could not stimulate PD-L1 expression on normal.
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PR Newswire 09/12/2019 13:03
CLEVELAND, Sept. 12, 2019 /PRNewswire/ -- "Sway: A Message of Perseverance and Faith," a new novel by Cleveland based author John Cicero, is an enthralling and spiritually themed fictional story rooted from personal life-altering experiences with cancer.
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