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PubMed News (NIH) 08/05/2020
Contributors : Zan Liu ; Yang Yang Series Type : Non-coding RNA profiling by array Organism : Homo sapiens. To determine the circRNA expression profile in BCa and matched non-tumor tissues, we uesed circRNA microArray analysis form Arraystar to examine the expression of circRNAs in BCa and matched non-tumor tissues.
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ClinicalTrials.gov 08/04/2020 07:24
Condition : Non-muscle Invasive Bladder Cancer Intervention : Drug: APL-1202 treatment Sponsor : Jiangsu Yahong Meditech Co.,Ltd. Completed.
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Although gemcitabine is the cornerstone of care for pancreatic ductal adenocarcinoma (PDA), patients lack durable responses and relapse is inevitable. While the underlying mechanisms leading to gemcitabine resistance are likely to be multifactorial, there is a strong association between activating gemcitabine metabolism pathways and clinical outcome. This study evaluated casein kinase 1 delta (CK1) as a potential therapeutic target for PDA and bladder cancer, in which CK1 is frequently overexpressed. We assessed the antitumor effects of genetically silencing or pharmacologically inhibiting CK1 using our in-house CK1 small-molecule inhibitor SR-3029, either alone or in combination with gemcitabine, on the proliferation and survival of pancre.
With the recent recognition of lipid metabolic alterations in bladder cancers, we studied the metabolic implications of cisplatin resistance using cisplatin-sensitive (T24S) and -resistant (T24R) bladder cancer cells.
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News-Medical.net 07/25/2020 00:02
Arquer is making thousands of its tests available free of charge to all NHS hospitals until the end of September to help urologists quickly assess patients with suspected bladder cancer and ease the ongoing cancer diagnosis crisis caused by COVID-19.
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A genome-wide association study of bladder cancer identifies a new susceptibility locus within SLC14A1, a urea transporter gene on chromosome 18q12.3.
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Business Wire 07/17/2020 08:00
The second presentation, titled “The diagnostic accuracy of Bladder EpiCheck in high-risk population,” evaluated the diagnostic accuracy of Bladder EpiCheck compared to cystoscopy and cytology, the current gold standard, among 167 consecutive patients with a history or suspicion of high-risk bladder cancer.
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Cancer Cell International 07/10/2020 20:00
Rapamycin prevents surgery-induced immune dysfunction in patients with bladder cancer.
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Then, the clinical significance of RRBP1 in bladder cancer was evaluated.
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FeedNavigator (EU) 07/02/2020 12:37
Because of difficulty in urinating, urine retention in the bladder accelerates bacterial growth, long-term indwelling catheterization and hemiplegia, the risk of urinary tract infections often increases [22.
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Immuno-Oncology News 07/02/2020 08:00
Today’s approval of Bavencio in the most common type of advanced bladder cancer underscores our commitment to advancing scientific innovation and transforming outcomes for people with genitourinary cancers,” said Andy Schmeltz , global president of Pfizer Oncology.
More from Immuno-Oncology News:
Cancer-related venous thromboembolisms (VTE) are associated with metastasis and reduced survival in patients with urothelial cancer of the bladder. Although previous reports suggest the contribution of tissue factor and podoplanin, the mechanistic linkage between VTE and bladder cancer cell–derived molecules is unknown. Therefore, we compared distinct procoagulant pathways in four different cell lines. In vitro findings were further confirmed by microfluidic experiments mimicking the pathophysiology of tumor blood vessels and in tissue samples of patients with bladder cancer by transcriptome analysis and immunohistology. In vitro and microfluidic experiments identified bladder cancer–derived VEGF-A as highly procoagulant because it promoted.
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