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Purpose:. Adjuvant therapy for small, node-negative HER2-positive breast cancer (HER2 + BC) is controversial. We aimed to identify the subgroup that would benefit most from adjuvant chemotherapy and trastuzumab. Experimental Design:. We reviewed records of patients with pT1N0M0 HER2 + BC treated at our institution from January 1, 1998, through October 31, 2009. We compared three groups: A, no adjuvant chemotherapy; B, adjuvant chemotherapy only; and C, adjuvant chemotherapy with trastuzumab. We evaluated disease-free survival (DFS), overall survival (OS), distant recurrence-free survival (DRFS), and breast cancer-specific survival (BCSS) in each group. Results:. We reviewed 587 consecutive patients with a median follow-up of 123.0 months. The
Background: Second-line treatment options for advanced pancreatic adenocarcinoma are currently limited. Eryaspase, asparaginase (ASNase) encapsulated in red blood cells (RBCs), is an investigational product under development. Following infusion, asparagine and glutamine are actively transported into RBCs where they are hydrolyzed by the encapsulated ASNase. We have recently reported the outcome of a randomized phase 2b study in patients with advanced pancreatic cancer whose disease progressed following first-line treatment (NCT02195180). Eryaspase in combination with gemcitabine monotherapy or FOLFOX combination therapy improved overall survival (OS) and progression-free survival (PFS). The safety profile of eryaspase was acceptable. The re.
Introduction: Pancreatic ductal adenocarcinoma (PDAC) shows a highly invasive and metastatic potential. Curative resection with multidisciplinary therapy is crucial for PDAC patients to improve the prognosis. It is also important to determine suitable regimen of neoadjuvant therapy (NAT) for locally advanced PDAC patients.Materials and Methods: In this study, 104 consecutive patients with BR PDAC who underwent pancreatectomy at Chiba University Hospital from Jan. 2008 to Dec. 2017 were retrospectively analyzed. We assessed the clinical significance of NAT compared to Surgery First (SF) in patients with borderline resectable (BR) PDAC. Furthermore, we compared the clinical impact between gemcitabine plus S-1 (GS) and gemcitabine plus nab-pac.
Business Wire 12/12/2019 11:45
STRASBOURG, France--(BUSINESS WIRE)-- #Transgene--Regulatory News: Transgene (Paris:TNG) (Euronext Paris: TNG), a biotech company that designs and develops virus-based immunotherapeutics against cancer, today announces that the primary endpoint (overall response rate) of the Phase 2 trial evaluating TG4010 in combination with chemotherapy and Opdivo® (nivolumab) was not reached.
ClinicalTrials.gov 12/12/2019 10:41
Conditions : Myeloid Neoplasm; Recurrent Acute Myeloid Leukemia; Refractory Acute Myeloid Leukemia Interventions : Drug: Cladribine; Drug: Cytarabine; Biological: Granulocyte Colony-Stimulating Factor; Drug: Mitoxantrone Sponsors : University of Washington; National Cancer Institute (NCI) Not yet recruiting.
PR Newswire 12/12/2019 06:00
For the group of patients with Recurrence Score results 11-25, there were no statistically significant differences in 10-year distant recurrence rates between patients who received chemotherapy and those treated with hormonal therapy alone.
We herein report the novel iron(III) activated lysosome‐targeting iridium(III) prodrug FerriIridium , for gastric cancer theranostics. This complex contains a m ‐imino catechol group which can selectively bond to, and be oxidized by, free iron(III) inside the cell. Subsequent oxidative rearrangement releases iron(II) and hydrolyses the amine bond in acidic conditions and an aminobipyridyl iridium complex and 2‐hydroxybenzoquinone are produced. This sequence of reactions has a threefold effect. First: iron (II) can catalyze the Fenton reaction transforming hydrogen peroxide into hydroxyl radicals. Second: benzoquinone compounds can interfere with the respiratory chain. Third: conversion from the prodrug to the amino‐iridium complex leads to

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