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FeedNavigator (EU) 08/17/2019 07:38
The biological effects of insulin signaling are regulated by the phosphorylation of insulin receptor substrate 1 (IRS1) at serine (Ser) residues. In the brain, phosphorylation of IRS1 at specific Ser sites increases in patients with Alzheimer’s disease (AD) and its animal models. However, whether the activation of Ser sites on neural IRS1 is related to any type of memory decline remains unclear. Here, we show the modifications of IRS1 through its phosphorylation at etiology-specific Ser sites in various animal models of memory decline, such as diabetic, aged, and amyloid precursor protein (APP) knock-in NL-G-F (APPKINL-G-F) mice. Substantial phosphorylation of IRS1 at specific Ser sites occurs in type 2 diabetes- or age-related memory defic.
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Forbes 08/16/2019 17:39
The Alzheimer's Association endorsed it as the foundation of its 2018 Dementia Care Practice Recommendations.
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CBC News (Canada) 08/16/2019 15:26
Beth Kallmyer, vice-president of care and support for the Alzheimer's Association in Chicago, manages a 24-hour help line staffed by specialists and other clinicians for people with dementia and their families.
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Scientists at MIT and MGH have gained new clues into the role of the brain’s blood-brain barrier in Alzheimer’s disease.
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... the researchers looked at previously published data on the efficacy of drugs in a model organism, the round worm, C. elegans, where one can trigger the formation of Amyloid b, a misfolded protein associated with Alzheimer's disease.
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Technology Org 08/16/2019 07:10
Population to personalization For their work, the researchers leveraged the world’s largest Alzheimer’s disease clinical trial dataset, called Alzheimer’s Disease Neuroimaging Initiative (ADNI.
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Health24 08/15/2019 23:23
Even mild anemia – low levels of haemoglobin in the blood – may raise a person's odds for Alzheimer's disease and other types of dementia, a new study finds.
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In addition, they suggest that a role for TREM2 in AD pathogenesis is not limited to carriers of AD risk variants in that gene.
More from Alzheimer's Research & Therapy: 08/15/2019 12:10
Researchers highlight a more basic underlying cause of the onset of Alzheimer’s disease The Canterbury researchers reviewed 33 studies which focused on dietary approaches for Alzheimer’s disease (AD.
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ETHealthWorld (India) 08/15/2019 11:00
The authors of the study published in the journal 'Alzheimer's Disease' also noted that "further studies are warranted to gain a better understanding of the underlying mechanisms of the migraine-dementia relationship and the different sexes in the association between migraine and dementia.
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Environmental News Network 08/15/2019 10:49
Environmental News Network - Tissue Model Reveals Role of Blood-Brain Barrier in Alzheimer’s.
More from Environmental News Network: 08/15/2019 08:44
The researcher will use 7 AD and 7 comparably aged cognitively normal successfully scanned subjects to calculate the microglial activation reserve index.
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Genetic Literacy Project 08/15/2019 07:01
The workshop participants published two papers on it in the August issue of Alzheimer’s and Dementia, and the NIA announced plans to fund relevant research next year.
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