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The anti-angiogenic treatment of advanced renal cell carcinoma (RCC) has evolved in the past 15 years owing to the introduction of several vascular endothelial growth factor receptor-tyrosine kinase inhibitors (VEGFR-TKIs) in clinical practice [1]. VEGFR-TKIs are commonly defined as first- or second-line drugs based on their clinical use [2]; however, a pharmacological classification should refer mainly to their pharmacodynamic and pharmacokinetic properties.
FeedNavigator (EU) 01/22/2020 06:38
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A macromolecular reporter whose near‐infrared fluorescence is activated by a bladder cancer biomarker and that efficiently undergoes renal clearance was synthesized. It was used for real‐time in vivo imaging and ex vivo urinalysis of bladder cancer in living mice. Abstract. Bladder cancer (BC) is a prevalent disease with high morbidity and mortality; however, in vivo optical imaging of BC remains challenging because of the lack of cancer‐specific optical agents with high renal clearance. Herein, a macromolecular reporter (CyP1) was synthesized for real‐time near‐infrared fluorescence (NIRF) imaging and urinalysis of BC in living mice. Because of the high renal clearance (ca. 94 % of the injection dosage at 24 h post‐injection) and its cancer.
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PubMed News (NIH) 01/18/2020 23:00
Contributors : Annika Fendler ; Kun Son ; Wei Chen ; Walter Birchmeier Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. We detected and characterized CXCR4+MET+CD44+ cancer stem cells (CSCs) that were quantitatively correlated with aggressive tumors.
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News-Medical.net 01/17/2020 07:19
Because kidney cancer is often resistant to the most advanced treatments, new therapies are critically needed, says Zhang, associate professor of pathology and a corresponding author of the study published online recently by Cancer Discovery.
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Lancet 01/16/2020 19:17
Brian Rini and colleagues reported the results of IMmotion151, a randomised controlled trial in patients with advanced renal cell carcinoma.
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NSD2 Promotes Renal Cancer Progression Through Stimulating Akt/Erk Signaling.
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ScienceDaily 01/15/2020 13:26
... today in Nature conclude that enrichment of B cells, a type of immune cell known for producing antibodies, in TLS was predictive of response to checkpoint blockade in patients with melanoma, soft-tissue sarcomas and renal cell carcinomas (RCC.
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The tumorigenic role and underlying mechanisms of lipid accumulation, commonly observed in many cancers, remain insufficiently understood. In this study, we identified an AMP-activated protein kinase (AMPK)–GATA-binding protein 3 (GATA3)–enoyl-CoA hydratase short-chain 1 (ECHS1) pathway that induces lipid accumulation and promotes cell proliferation in clear cell renal cell carcinoma (ccRCC). Decreased expression of ECHS1, which is responsible for inactivation of fatty acid (FA) oxidation and activation of de novo FA synthesis, positively associated with ccRCC progression and predicted poor patient survival. Mechanistically, ECHS1 downregulation induced FA and branched-chain amino acid (BCAA) accumulation, which inhibited AMPK-promoted expr.
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Medindia.com 01/14/2020 06:35
Renal tuberculosis is caused by Mycobacterium tuberculosis, which is a common cause of respiratory infection especially in the low socio-economic regions of the underdeveloped and developing countries.
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Human medicines European public assessment report (EPAR): Aranesp, darbepoetin alfa, Anemia,Cancer,Kidney Failure, Chronic, Date of authorisation: 08/06/2001, Revision: 42, Status: Authorised.
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ClinicalTrials.gov 01/09/2020 07:43
In the last decade, investigators from the Department of Cancer Epidemiology and Genetics (National Cancer Institute, USA) have conducted genome-wide association (GWAS) studies of renal cell carcinoma.
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ETHealthWorld (India) 01/04/2020 01:00
But even a cursory look at the medical facilities available at gas relief hospitals , including Bhopal Memorial Hospital & Research Centre (BMHRC), would show that there is no expert for treatment of renal disorder , cancer and trouble in respiratory system in any of those hospitals.
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Targeted Oncology 01/03/2020 11:46
Individuals with obesity who were diagnosed with locally advanced or metastatic clear cell renal cell carcinoma (ccRCC) achieved longer overall survival (OS) than patients of normal weight in select groups of an independent cohort study, which evaluated OS and the transcriptomic differences in the primary tumor and peritumoral adipose tissue in ...
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Receptor tyrosine kinase inhibitors have shown clinical benefit in clear cell renal cell carcinoma (ccRCC), but novel therapeutic strategies are needed.
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