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A study published earlier this year provided the first compelling evidence that inflammation in the mouth can increase your risk of Alzheimer’s.
More from Mail on Sunday (United Kingdom): 09/19/2019 23:42
These inflammatory molecules accumulate and cause the pathology of disease, including but not limited to: Alzheimer’s.
More from 09/19/2019 23:40
To confirm they had identified a potential drug target, Dr Martínez-Mármol knocked out the enzyme in mice with Alzheimer's disease and found the levels of plaques in the brain and the inflammatory response were all back to normal.
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BIOENGINEER.ORG 09/19/2019 13:26
The researchers suggest a comprehensive assessment of all the modifiable environmental factors associated with cognitive aging and Alzheimer’s disease, including diet, exercise, air pollution, socio-economic status, toxins, traumatic brain injuries, stress, inflammation, infections, hypertension, cells and gender.
FeedNavigator (EU) 09/19/2019 09:03
To date, most therapies for AD have targeted amyloid-β or tau.
More from FeedNavigator (EU):
Chem. Sci. , 2019, Accepted Manuscript DOI : 10.1039/C9SC03042E, Edge Article. Open Access. This article is licensed under a. Tao Yang, Zhenzhu Zhu, Enmao Yin, Yanqing Wang, Changli Zhang, Hao Yuan, Hongmei Zhang, Suxing Jin, Zijian Guo, Xiaoyong Wang Alzheimer’s disease (AD) is one of the most prevailing neurodegenerative illnesses in the elderly. Accumulation of amyloid-β peptide (Aβ) and inflammation play critical roles in the pathogenesis and development of... The content of this RSS Feed © The Royal Society of Chemistry. 09/18/2019 07:52
The present studies demonstrated that pro-inflammation, systemic oxidative stress and dysfunction in the brain-gut microbiota axis were involved in Alzheimer's disease (AD) pathogenesis.
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GlobeNewswire 09/18/2019 07:30
Patients treated with TTP399 had improved Time in Range (TIR), reduced time in hyperglycemia, fewer hypoglycemic events, and lower bolus insulin dose. Patients treated with TTP399 had improved Time in Range (TIR), reduced time in hyperglycemia, fewer hypoglycemic events, and lower bolus insulin dose.
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Benzinga 09/17/2019 16:35
The thinly traded micro-cap biotech vTv Therapeutics Inc (NASDAQ: ) is on investors' radars ahead of a Sept. 18 poster presentation of clinical data. The company is set to present at the European Association for the Study of Diabetes 55th annual meeting with results from the Part 1 of the Phase 2 Simplici-T1 study of liver-selective glucokinase activator TTP399 as an adjunctive treatment for Type 1 diabetes. The Pipeline. vTv has six products in its clinical pipeline, with three Phase 2 assets: azeliragon for Alzheimer's disease, TTP399 for Type 1 and Type 2 diabetes and TTP273 for Type 2 diabetes. Azeliragon. codenamed TTP488, is an orally administered, small molecule antagonist targeting the receptor of advanced glycation endproducts, or RA.
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ENDPOINTS 09/17/2019 05:00
Psychedelics have experienced recent years amid a torrent of preclinical and clinical research suggesting it might provide a path to treat mood disorders conventional remedies have only scraped at. Now a preclinical trial from a young biotech suggests at least one psychedelic compound has effects beyond the mind, and — if you believe the still very, very early hype — could provide the first single remedy for some of the main complications of obesity. A study in mice funded by Eleusis and published in Scientific Reports found a long-known drug called ®-DOI could be used to treat cardiovascular disease, reducing inflammation in the aorta, decreasing overall and HDL cholesterol levels, and potentially curbing diabetes by increasing glucose tol.
Innovations-Report (EU) 09/16/2019 10:35
Researchers at the Complutense University of Madrid (UCM) have identified changes in retinal layer thickness, inflammation or thinning in patients with mild Alzheimer's disease, confirming that the retina is one of the most important biomarkers for early diagnosis of the disease. For the first time, researchers have determined the shape and size of the areas that present significant thinning in each retinal layer, which tend to occur in...
PubMed News (NIH) 09/16/2019
Contributors : Christoph Gericke ; Anna Mallone ; Britta Engelhardt ; Roger M Nitsch ; Maria T Ferretti Series Type : Expression profiling by high throughput sequencing Organism : Mus musculus. The goal of this study is to investigate the involvement of inflammation in Alzheimer’s disease (AD) and to clarify the signaling pathways involved in the presence of beta-amyloidosis, a hallmark of AD pathogenesis, to help identifying potential targets for therapy.
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