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FeedNavigator (EU) 09/15/2020 10:42
Nuclear factor of activated T cells 5 (NFAT5), a Rel/nuclear factor- (NF-) κ B family member, is the only known gene regulator of the mammalian adaptive response to osmotic stress. Exposure to elevated glucose increases the expression and nuclear translocation of NFAT5, as well as NFAT5-driven transcriptional activity in vivo and in vitro. Increased expression of NFAT5 is closely correlated with the progression of diabetes in patients. The distinct structure of NFAT5 governs its physiological and pathogenic roles, indicating its opposing functions. The ability of NFAT5 to maintain cell homeostasis and proliferation is impaired in patients with diabetes. NFAT5 promotes the formation of aldose reductase, pathogenesis of diabetic vascular comp.
Until now, researchers have relied on computational prediction to match a cell's epigenome to a single-cell gene expression profile. Rather than taking each measurement separately and inferring their linkage through computational methods, 10X Genomics has devised a system capable of simultaneously profiling the epigenome and transcriptome simultaneously from the same single cell. .
Disease Models & Mechanisms 09/15/2020 03:16
ABSTRACT. Neonatal and infant immunity differs from that of adults in both the innate and adaptive arms, which are critical contributors to immune-mediated clearance of infection and memory responses elicited during vaccination. The tuberculosis (TB) research community has openly admitted to a vacuum of knowledge about neonatal and infant immune responses to Mycobacterium tuberculosis (Mtb) infection, especially in the functional and phenotypic attributes of memory T cell responses elicited by the only available vaccine for TB, the Bacillus Calmette–Guérin (BCG) vaccine. Although BCG vaccination has variable efficacy in preventing pulmonary TB during adolescence and adulthood, 80% of endemic TB countries still administer BCG at birth because.


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