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This marker rises early in AD and thus far appears specific for amyloid-driven tau pathology (Mar 2020 news.
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BIOENGINEER.ORG 08/14/2020 14:22
Scientists found that when genes required for this pathway are deleted, Alzheimer’s disease progression accelerates in a mouse model.
The Department of Commerce (Commerce) preliminarily determines that countervailable subsidies are being provided to producers and exporters of common alloy aluminum sheet (aluminum sheet) from The Republic of Turkey (Turkey). The period of investigation is January 1, 2019 through December 31, 2019. Interested parties are invited to comment on this preliminary determination.
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PubMed News (NIH) 08/14/2020
Contributors : A Ndoja ; R Reja Series Type : Genome binding/occupancy profiling by high throughput sequencing Organism : Mus musculus. The realization in the last decade that dysregulated microglia are intimately involved in Alzheimer’s disease (AD) pathogenesis has been a major advance.
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FeedNavigator (EU) 08/13/2020 13:09
Diabetic peripheral neuropathy (DPN) is the most common complication of type 2 diabetes (T2D). Although the cellular and molecular mechanisms of DPN are poorly understood, we and others have shown that altered gene expression and DNA methylation are implicated in disease pathogenesis. However, how DNA methylation might functionally impact gene expression and contribute to nerve damage remains unclear. Here, we analyzed genome-wide transcriptomic and methylomic profiles of sural nerves from T2D patients with DPN. Unbiased clustering of transcriptomics data separated samples into groups, which correlated with HbA1c levels. Accordingly, we found 998 differentially expressed genes (DEGs) and 929 differentially methylated genes (DMGs) between th.
More from FeedNavigator (EU): 08/12/2020 02:06
Malfunctioning microglia are associated with many neurological diseases such as Alzheimer's, ALS and Parkinson's.
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GlobeNewswire 08/11/2020 16:05
The Company’s product candidates are supported by biomarkers and target genetically defined patient populations in frontotemporal dementia and Alzheimer’s disease.
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Fight Aging! 08/10/2020 06:11
Chronic inflammation in brain tissue is an important component of the progression of neurodegenerative conditions such as Alzheimer's disease. It is important enough that some researchers propose inflammation resulting from persistent infection and cellular senescence to be the primary mechanism in Alzheimer's disease, and the characteristic accumulation of amyloid-β deposits only a side-effect. Given the failure to achieve meaningful benefits in patients through removal of amyloid-β, researchers are turning their eyes towards ways to suppress inflammatory signaling in the brain. Removal of senescent cells, the source of a great deal of that inflammatory signaling, is one promising avenue, but other efforts focus on interference in specific.
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Big Think 08/07/2020 13:14
While the exact cause of Alzheimer's remains unknown, researchers are targeting toxic beta-amyloid buildup. A recent study on mice found oxytocin could be a protective agent against plaque buildup. Though more research needs to be conducted, this is a hopeful sign in our fight against a crippling disease. While Americas watch the battle for the most cognitively-fit president unfold on social media and television, the problem pundits are really discussing is dementia.
Seeking Alpha 08/07/2020 12:34
COVID-19 drove a double-digit sequential decline in U.S. Onpattro revenue, but both Onpattro and Givlaari revenue exceeded expectations, with management lifting the lower end of its Onpattro revenue forecast.
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