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PubMed News (NIH) 08/12/2020
Status Public on Aug 12, 2020 Title Integrated genomic analysis of chromosomal alterations and mutations in B-cell acute lymphoblastic leukemia reveals distinct genetic profiles at relapse Organism Homo sapiens Experiment type Genome variation profiling by genome tiling array Summary Background: The clonal basis of relapse in acute lymphoblastic leukemia (ALL) is complex and not fully understood ...
PubMed News (NIH) 08/09/2020
Contributors : Minsoo Kim ; Elizabeth Vierling Series Type : Genome binding/occupancy profiling by high throughput sequencing Organism : Arabidopsis thaliana. To identify possible mitochondrial DNA binding targets of SHOT1/MTERF18 (AT3G60400), C-terminal GFP fusion constructs under either a constitutive 35S promoter (35S::SHOT1-GFP) or the SHOT1 native promoter (SHOT1p::SHOT1-GFP) were made.
PubMed News (NIH) 08/07/2020
Contributors : Ujué Fresán ; Maria Rodríguez-Sánchez ; Oscar Reina ; M L Espinàs Series Type : Genome binding/occupancy profiling by high throughput sequencing Organism : Drosophila melanogaster. Drosophila Haspin kinase phosphorylates Histone H3 at threonine 3 at centromeric heterochromatin and either lamin- or polycomb-enriched euchromatic regions, being required for nuclear organization of interphase cells and polycomb-dependent gene silencing.
PubMed News (NIH) 08/06/2020
Contributors : Atsushi Suzuki ; Yasuyuki Ohkawa ; Masao Nagasaki ; Kenichi Horisawa ; Kazuko Ueno Series Type : Genome binding/occupancy profiling by high throughput sequencing Organism : Mus musculus. We have found three specific combinations of two transcription factors, comprising Hnf4alpha plus Foxa1, Foxa2, or Foxa3, could convert mouse embryonic fibroblasts (MEFs) into cells that closely resemble hepatocytes (iHep cells) in vitro.
PubMed News (NIH) 08/04/2020
Contributors : Yahya Benslimane ; Thierry Bertomeu ; Jasmin Coulombe-Huntington ; Mary McQuaid ; María Sánchez-Osuna ; David Papadopoli ; Daina Avizonis ; Mariana S Russo ; Caroline Huard ; Ivan Topisirovic ; Hugo Wurtele ; Mike Tyers ; Lea Harrington Series Type : Other Organism : Homo sapiens. Using genome-wide CRISPR-Cas9 screens and other cell-based assays, we show that the pro-longevity agent resveratrol and its analogue pterostilbene induce a genetic signature of replicative stress that is similar to hydroxyurea.
PubMed News (NIH) 07/30/2020
Contributors : Laia Richart ; Eleonora Lapi ; Vera Pancaldi ; Mirabai Cuenca ; Enrique Carrillo-de-Santa-Pau ; Miguel Madrid-Mencia ; Helene Neyret-Kahn ; François Radvanyi ; Juan A Rodríguez ; Yasmina Cuartero ; François Serra ; Dily Francois ; Alfonso Valencia ; Marc A Marti-Renom ; Francisco X Real Series Type : Other Organism : Homo sapiens. Cohesin exists in two variants, containing either STAG1 or STAG2.
PubMed News (NIH) 07/23/2020
Contributors : Fabian Grubert ; Rohith Srivas ; Damek V Spacek ; Maya Kasowski ; Marian Ruiz Velasco ; Nasa Sinnott-Armstrong ; Peyton Greenside ; Anil Narasimha ; Qing Liu ; Benjamin Geller ; Akshay Sanghi ; Michael Kulik ; Silin Sa ; Marlene Rabinovitch ; Anshul Kundaje ; Stephen Dalton ; Judith Zaugg ; Michael P Snyder Series Type : Genome binding/occupancy profiling by high throughput sequencing Organism : Homo sapiens. Physical interactions between distal regulatory elements in the genome play a key role in regulating gene expression, yet the extent to which these interactions vary between cell types and contribute to cell type-specific gene expression patterns remains unclear.
PubMed News (NIH) 07/20/2020
Contributors : Jeanette A Johansson ; Robert S Illingworth ; E E Patton Series Type : Genome binding/occupancy profiling by high throughput sequencing Organism : Homo sapiens. To determine the role of PRL3 in gene regulation, empty vector or HA-tagged PRL3 was stably expressed in cultured human melanoma A375 cells.

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