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PubMed News (NIH) 01/23/2020 23:00
Contributors : Chris Bryan ; Chongli Yuan ; Jennifer Freeman Series Type : Methylation profiling by high throughput sequencing Organism : Danio rerio. We exposed zebrafish embryos to 0.3, 3, and 30 ppb (µg/L) of ATZ for 72 hours post fertilization. We performed whole-genome bisulfite sequencing (WGBS) to assess the effects of developmental ATZ exposure on DNA methylation in female fish brains.
PubMed News (NIH) 01/23/2020 23:00
Contributors : Ijeoma Okeigwe ; Serdar Bulun ; Shimeng Liu ; Alfred W Rademaker ; John S Coon ; Stacy Kujawa ; Jared Robins ; Ping Yin Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. Purpose: To investigate the function of PLIN2 in human uterine leiomyoma tumorigenesis, we generated genome-wide transcription profile of leiomyoma cells after PLIN2 knockdown.
PubMed News (NIH) 01/21/2020 23:00
Contributors : Wei-Yi Chen ; Xiaoling Wang ; Rebert G Roeder Series Type : Genome binding/occupancy profiling by high throughput sequencing Organism : Mus musculus. Mammalian cells contain two isoforms of RNA Polymerase III (Pol III) that differ in only a single subunit, with POLR3G in one form and the related POLR3GL in the other form.
PubMed News (NIH) 01/20/2020 23:00
Contributors : Shinji Tanaka ; Hidewaki Nakagawa Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. Background: The tumor microenvironment can be classified into immunologically active "inflamed" tumors and inactive "non-inflamed" tumors based on the infiltration of cytotoxic immune cells.
PubMed News (NIH) 01/20/2020 23:00
Contributors : Kristin N Falkenstein ; Zhicheng Ji ; Hongkai Ji ; Steven A Vokes Series Type : Genome binding/occupancy profiling by high throughput sequencing Organism : Mus musculus. Purpose: The response to Hedgehog signaling in the limb is driven by GLI bound enhancers and the majority of Hh targets in the developing limb bud are regulated solely by the activity of GLI-repressor.
PubMed News (NIH) 01/20/2020 23:00
Contributors : Rachel K Lex ; Weiqiang Zhou ; Hongkai Ji ; Steven A Vokes Series Type : Genome binding/occupancy profiling by high throughput sequencing Organism : Mus musculus. Purpose: The response to Hedgehog signaling in the limb is driven by GLI bound enhancers and the majority of Hh targets in the developing limb bud are regulated solely by the activity of GLI-repressor.
PubMed News (NIH) 01/13/2020 23:00
Status Public on Jan 14, 2020 Title Genomic Landscape and Therapeutic Targets of Adenosquamous Carcinoma of the Pancreas [ATAC-seq] Organism Homo sapiens Experiment type Genome binding/occupancy profiling by high throughput sequencing Summary We applied DNA content flow cytometry to a series of adenosquamous cancer of the pancreas (ASCP) tumor samples and patient derived xenografts ...
PubMed News (NIH) 01/12/2020 23:00
Contributor : Lishuang Qi Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. Gene expression estimates detected by RNA-sequencing technology vary with the updates of reference genome and gene annotation, which might confound existing expression-based prognostic signatures, making them inapplicable to clinical practice.
PubMed News (NIH) 01/12/2020 23:00
Contributors : Ginevra Brocca ; Massimo Castagnaro Series Type : Genome variation profiling by genome tiling array Organism : Canis lupus familiaris. The aim of this work was to identify the Copy Number Aberrations (CNAs) by high-resolution array Comparative Genomic Hybridization (aCGH) on 19 formalin-fixed, paraffin-embedded (FFPE) samples of treatment-naïve COM.
PubMed News (NIH) 01/07/2020 23:00
Contributors : Paul Brighton ; Maruyama Yojiro ; Katherine Fishwick ; Pavle Vrljicak ; Shreeya Tewary ; Risa Fujihara ; Joanne Muter ; Emma S Lucas ; Taihei Yamada ; Andrew Sharkey ; Laura Woods ; Raffaella Lucciola ; Saturo Takeda ; Sascha Ott ; Myriam Hemberger ; Siobhan Quenby ; Jan J Brosens Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. We use RNA-sequencing to measure global transcription in LH timed endometrial biopsies of 10 women aged ≤ 30 years and 10 women aged ≥ 40 years.

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