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PubMed News (NIH) 06/01/2020
Contributors : Christopher A Odhams ; Andrea Cortini ; Timothy J Vyse ; Deborah S Cunninghame Graham Series Type : Genome binding/occupancy profiling by high throughput sequencing Organism : Homo sapiens. The Ikaros family transcription factors Helios (IKZF2) and Aiolos (IKZF3), critical to lymphocyte homeostasis, are genetically associated with multiple immunological disorders including the prototypic autoimmune disease SLE.
PubMed News (NIH) 06/01/2020
Contributors : Jean-Phillippe Morretton ; Aurelie Herbette ; Pierre Gestraud ; Geoges Lucottes ; Philippe La Rosa ; Oumou Goundiam ; Renata Basto Series Type : Genome variation profiling by genome tiling array Organism : Homo sapiens. In order to check if there is a correlation between centrosome alterations and DNA breakpoints or homologous recombination defects (HRD) assesssed by LST genomic signatures, we used Affimetrix cytoscan array and GAP tool as previously described in Goundiam et al, IJC 2015 (PMID:25892415 DOI:10.1002/ijc.29568 ) 67 high grade serous ovarian cancers.
PubMed News (NIH) 06/01/2020
Contributors : Lina Cordeddu ; Lee Siggens ; Karl Ekwall Series Type : Genome binding/occupancy profiling by high throughput sequencing Organism : Homo sapiens. The histone 3 lysine 4 (H3K4) monomethylase KMT2C is mutated across several cancer types, however the effects of mutations on epigenome organization, gene expression and cell growth are not clear.
PubMed News (NIH) 05/29/2020
Contributors : Mathieu Boulard ; John R Edwards ; Timothy H Bestor Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing Organism : Mus musculus. Methylated mammalian promoters are transcriptionally silenced even in the presence of all the factors required for their expression.

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