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Population-based cancer registries provide a potential platform to overcome problems with inclusion of diverse patient populations in clinical research if they are used as a source for recruitment.
Our central hypothesis is that differences in ancestry-related single nucleotide polymorphisms (SNPs), gene expression and/or metabolites will associate with prostate-specific antigen (PSA) response and time to progression on secondary hormonal therapy in mCRPC patients.
Cox proportional hazard models were used to examine the association between time-varying air pollutants and mortality, accounting for age at diagnosis, race/ethnicity, marital status, chemotherapy, hormone therapy, radiation, surgery, stage, grade, hormone receptor status, tumor size, body mass index, smoking, alcohol, age at first birth, diabetes, CVD, and neighborhood socioeconomic status.
In comparison to urban-dwelling patients, rural residents traveled an average of 36 vs 17 miles for surgery (p<0.01), 37 vs. 17 miles for chemotherapy (p<0.01), 34 vs. 16 miles for radiation therapy (p<0.01), and 23 vs 6 miles for hormone therapy (p=0.01.

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