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Medical Xpress - Cancer News 02/25/2020 10:15
Scientists at St. Jude Children's Research Hospital, alongside collaborators around the world, have created a comprehensive reference of functional variants in an important drug-metabolizing enzyme called NUDT15. This thorough understanding of NUDT15 variants provides an invaluable resource for predicting which patients being treated with thiopurine drugs for acute lymphoblastic leukemia (ALL) are likely to experience toxicity. The work was published today in Proceedings of the National Academy of Science.
Medical Xpress - Cancer News 02/25/2020 02:55
Healthy women over the age of 75 years might not benefit from continuing breast cancer screening. Researchers used data from the Medicare program to estimate the risk of breast cancer mortality under two strategies: continuing versus stopping screening in older women. They found a small mortality benefit for continuing to screen women between the ages of 70 to 74, but not those between 75 to 84. Findings from this population-based observational study are published in Annals of Internal Medicine.
Medical Xpress - Cancer News 02/25/2020 02:54
All life is challenged by oxidants—reactive molecules or compounds that remove electrons from other molecules—often with adverse effect, commonly referred to as oxidative stress. Consequently, all organisms have evolved specialized antioxidant defenses. In humans and other multicellular animals, that defense depends upon a protein called NRF2 and its inhibitor, KEAP1.
Medical Xpress - Cancer News 02/24/2020 08:03
U.S. life expectancy increased in 2018 after a worrisome four-year decline, a reversal owing in part to a welcome decrease in deaths due to overdose but even more so to a drop in those from cancer. The rise brought the anticipated lifespan of someone born in 2018 to 78.7 years, an increase of about a month from 2017 but still short of the 78.9 years reached in 2014. The 2018 figure also included easing in mortality from heart disease and lung disease. The reduction in deaths from cancer, the nation's No. 2 killer, occurred as rapid advances are being made in treatment with newly developed immunotherapies and precision targeting of tumors' genetic profiles as well as in detection and prevention. The Gazette spoke to Timothy Rebbeck, the Vinc.
Medical Xpress - Cancer News 02/20/2020 12:41
Researchers at the USC Viterbi School of Engineering have designed a new drug cocktail that kills some types of brain and soft tissue cancers by tricking the cancer cells to behave as if they were starving for their favorite food—glucose. The researchers' findings were recently published in the Journal of Biological Chemistry and may pave the way for targeted cancer treatments with greater efficacy and less harmful side effects.
Medical Xpress - Cancer News 02/11/2020 15:21
The hormone estrogen plays many critical roles in men and women, in both healthy tissues and in cancer. In breast and gynecologic cancers, estrogen sends signals to tumors instructing the cancer cells to grow out of control. In recent years, studies have shed light on the growth-promoting role of estrogen in breast cancer. In endometrial cancer, which arises in the lining of the uterus, estrogen is known to play a critical role in tumor development, yet many insights from how it affects breast cancer do not apply to endometrial cancer. New research, published today in the journal Cancer Research, outlines findings scientists hope will advance our understanding of endometrial cancer and lead to more effective treatments.
Medical Xpress - Cancer News 02/11/2020 11:10
Transitions in breast cancer care are associated with significant increases in stress and anxiety, and this stress can negatively impact the mental and physical health of patients. Increasingly, patients are seeking support from friends and family through social media, including Facebook. A new study from the University of Minnesota School of Public Health examined the posting behavior of breast cancer patients on Facebook and offers details on how—and possibly why—it changed over time.
Medical Xpress - Cancer News 02/04/2020 09:19
Women who have sex with women (WSW), transsexual men and non-binary people with a cervix are at similar risk of human papillomavirus (HPV) infection and subsequent risk of developing cervical cancers as heterosexual women, but are often never screened or underscreened, according to the authors of a Lessons from Practice article published online by the Medical Journal of Australia.
Medical Xpress - Cancer News 02/03/2020 16:39
Uveal melanoma—a cancer found in the eye—is rare, comprising less than 5% of all melanomas. Despite successful treatment of the primary tumor in the eye, up to 50% of patients will develop systemic spread (metastasis), most commonly in the liver. A recent study from Massachusetts Eye and Ear Infirmary reported that prognosis of uveal melanoma patients with metastasis is very poor with a median survival of 3.9 months after diagnosis. They also suggested there has been no improvement in care over decades of treatment of metastatic disease. In contrast, new research from The Sidney Kimmel Cancer Center (SKCC) - Jefferson Health investigating uveal melanoma patients with liver metastasis treated at Jefferson showed that outcomes of these patien.
Medical Xpress - Cancer News 01/31/2020 11:00
In the first comparative clinical trial of lung cancer screening decision aid versus standard educational information, researchers from The University of Texas MD Anderson Cancer Center have shown that a decision aid delivered through tobacco quitlines effectively reaches a screening-eligible population and results in informed decisions about lung cancer screening.
Medical Xpress - Cancer News 01/31/2020 10:05
The closing of rural hospitals and specialty care units is causing many people, including breast cancer patients, to seek treatment far from home. A study from the University of Minnesota School of Public Health recently found that U.S. rural breast cancer patients typically travel three times farther than urban women for radiation therapy to treat their disease.
Medical Xpress - Cancer News 01/30/2020 09:10
A team of researchers affiliated with multiple institutions in Massachusetts has discovered some of the precancerous milestones that can lead to breast cancer in women with a BRCA2 gene mutation. In their paper published in the journal Science Advances, the group describes their detailed analysis of breast tissue taken from women with the mutation who elected to undergo a mastectomy, and what they found.

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