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Business Wire 05/29/2020 12:37
For years, researchers have studied the utility of biomarkers for understanding, detecting and monitoring Alzheimer’s disease.
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News-Medical.net 05/27/2020 22:15
Research provides new evidence for potential blood-based biomarker for Alzheimer's.
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British people with two copies of a particular gene which is a biomarker of Alzheimer's disease are found to be at a markedly higher risk of COVID-19 finds a new analysis of the U.K. Biobank data. The APOE4 allele was found to be influencing people to develop COVID-19 twice that of the gene APOE3, reported the researchers at the University of Exeter in England.
Alzforum News 05/26/2020 19:06
The plasma biomarker neurofilament light was able to distinguish individual mutation carriers from noncarriers three years prior to onset.
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PR Newswire 05/26/2020 09:48
STOCKHOLM, May 26, 2020 /PRNewswire/ -- BioArctic AB (publ) (Nasdaq Stockholm: BIOA B) announces that seven members of the company's Board and management today have exercised options to purchase shares in the company in accordance with the existing option agreements with the principal...
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Neurofilament proteins are thought to reflect axonal damage, and NfL is a CSF biomarker for AD.
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Seeking Alpha 05/23/2020 13:52
Kadmon goes up on positive data. Anavex proceeds with early stage trial. Entera down on poor interim data.
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FeedNavigator (EU) 05/22/2020 07:37
As an early event in the pathogenesis of AD, chronic inflammation could be considered as a potential biomarker in the treatment strategies for AD.
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BioNewsFeeds 05/18/2020 11:00
Cassava Sciences‘s investigational therapy PTI-125 failed to significantly lower the levels of Alzheimer’s-relevant biomarkers present in fluid surrounding the brain and spinal cord of patients, according to results from a Phase 2b clinical trial.
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GlobeNewswire 05/18/2020 08:00
ESCAPE study to recruit 40 patients. ESCAPE study to recruit 40 patients.
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Healio News 05/13/2020 16:41
Howard A. Fink A series of review articles found limited or inconsistent data supporting the accuracy of biomarkers and cognitive tests for diagnosing and differentiating Alzheimer’s disease, as well as drug treatments that minimally impacted functional decline.
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PubMed News (NIH) 05/13/2020
Contributor : Meer Mustafa Series Type : Expression profiling by high throughput sequencing Organism : Mus musculus. TREM2 is a receptor for lipids expressed in microglia. The R47H variant of human TREM2 impairs ligand binding and increases Alzheimer’s Disease (AD) risk. In mouse models of amyloid b (Ab) accumulation, defective TREM2 function affects microglial response to Ab plaques exacerbating tissue damage, whereas TREM2 overexpression attenuates pathology. Thus, AD may benefit from TREM2 activation. Here, we examined the impact of an anti-human TREM2 agonistic mAb, AL002c, in a mouse AD model expressing either the common variant (CV) or the R47H variant of TREM2. Single cell RNA-seq of microglia after acute systemic administration of AL.
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Benzinga 05/07/2020 08:30
The Company's product candidates are supported by biomarkers and target genetically defined patient populations in frontotemporal dementia and Alzheimer's disease.
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