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It has long been recognised that genetically inherited (familial) Alzheimer's disease is caused by mutations in a group of proteins within the human brain known as the gamma secretase complex.
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FeedNavigator 03/22/2019 06:57
FASEB J. 2019 Mar 20:fj201802718R. doi: 10.1096/fj.201802718R. [Epub ahead of print]
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FierceBiotech 03/22/2019 05:31
Albert Einstein is often attributed as saying: “The definition of insanity is doing the same thing over and over again, but expecting different results.” He likely didn’t actually say this, but regardless of its origins, this witticism comes sharply into focus when you read Eisai’s PR about starting new trials for BAN2401.
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Science 03/22/2019 02:50
We’ve known that APOE4 [an important Alzheimer’s risk gene] is much less of a risk factor in the African-American population, even though Alzheimer’s is much more common.
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Fight Aging! 03/21/2019 16:05
In recent years researchers have investigated changes in alternative splicing in the context of aging and age-related disease. It is thought to be important in cellular senescence, for example, but that is just one line item in the bigger picture. A given gene can code for multiple different proteins, and alternative splicing is the name given to the processes by which those different proteins are produced. A gene contains discrete DNA sequences called exons and introns, the former passed into the protein production process, and the latter removed during RNA splicing. The canonical protein produced from this genetic blueprint contains all of the exons, joined in sequence, but alternative splicing may drop exons, resulting in a different pro.
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ClinicalTrials.gov 03/21/2019 09:52
In this current study, REST protein content and gene polymorphism will be obtained in peripheral blood in AD and normal control.
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News-Medical.net 03/21/2019 04:03
Researchers assess all participants' memories at the beginning and end of the study, and some participants also complete magnetic resonance imaging (MRI) and testing for a gene associated with Alzheimer's disease.
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Newsweek 03/20/2019 09:55
Lack of sleep is linked to high blood pressure, heart disease, diabetes, Alzheimer’s and even to cells’ ability to repair errant genes.
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Medical Xpress 03/19/2019 13:01
The researchers, members of the International Genomic Alzheimer's Project (IGAP), analyzed both rare and common gene variants in 94,437 individuals with late onset Alzheimer's disease, the most common form of dementia in older adults.
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Singularity HUB 03/19/2019 10:00
Three years back, in a strobe of insight, her team decided to stick mice engineered with a genetic predisposition to Alzheimer’s disease under flashing lights.
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