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More from Federal Register - Public Inspection (OFR): 02/19/2020 16:28
Researchers from Florida Atlantic University and collaborators conducted one of the first known studies to examine how cognitive functioning is affected differently by the neighborhood environment depending on one's apolipoprotein E (APOE) genotype - a genetic risk factor for Alzheimer's disease (AD.
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Business Wire 02/19/2020 08:00
SAN FRANCISCO--(BUSINESS WIRE)--ESCAPE Bio, Inc., a clinical stage company developing novel, precisely targeted therapeutics for genetically defined neurodegenerative diseases, today announced that Julie Anne Smith, Chief Executive Officer, will present at the 9th Annual SVB Leerink Global Healthcare Conference on Tuesday, February 25, 2020.
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Researchers in Japan have identified a new quality control system that cells use to remove damaged and potentially toxic proteins—including amyloid β (Aβ) that is associated with Alzheimer’s disease (AD)—from the extracellular space. Their studies showed that the chaperone protein Clusterin shuttles misfolded proteins directly into cells for degradation, via cell surface heparan sulfate receptors. .
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Fight Aging! 02/19/2020 06:22
Researchers here provide evidence for significant levels of cell death to occur in the brain earlier than expected in the development of Alzheimer's disease, during the stage of mild cognitive impairment thought to be driven by the aggregation of amyloid-β.
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Nature 02/19/2020
Nature, Published online: 19 February 2020;. Nigeria is poised to become a hub for genetics research, but a few stubborn challenges block the way.
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PubMed News (NIH) 02/18/2020 23:00
Interestingly, distinct sets of genes are affected at different stages of adult fly life with IR occurring at several AD-associated genes in old adult.
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FeedNavigator (EU) 02/18/2020 11:23
Background: Several natural products have been reported to elicit beneficial effects against neurodegenerative disorders due to their vitamin E contents. However, the neuroprotective efficacy of palm oil or its tocotrienol-rich fraction (TRF) from the pre-clinical cell and animal studies have not been systematically reviewed. Methods: The protocol for this systematic review was registered in “PROSPERO” (CRD42019150408). This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The Medical Subject Heading (MeSH) descriptors of PubMed with Boolean operators were used to construct keywords, including (“Palm Oil”[Mesh]) AND “Nervous System”[Mesh], (“Palm Oil”[Mesh]) AND “Neurodegenerative D.
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Funding Opportunity RFA-AG-21-015 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications to establish a network to identify, evaluate, track, and conduct research across multiple sites on older adults with superior cognitive performance for their age ("cognitive super agers"). The activity would support aggregation of sufficient numbers of these individuals to advance the fields understanding of factors that promote sustained cognitive health and those that are not of primary importance. Uniform identification and uniform data collection will allow the study of the behavioral, neurological, health, genetic, environmental, and lifestyle profiles that lead to sustained cognitive and brain.
A study published in JAD from researchers at McGill University led by Dr. Claudio Cuello of the Department of Pharmacology and Therapeutics, has shown that, when given in a formulation that facilitates passage to the brain, lithium in doses up to 400 times lower than what is currently being prescribed for mood disorders is capable of both halting signs of advanced Alzheimer's pathology such as amyloid plaques and of recovering lost cognitive abilities. 02/13/2020 13:58
Studies also point to a mutation in the gene encoding for filaggrin as another contributor to AD.
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Seeking Alpha 02/13/2020 04:56
The unusual thing about this trial was that it was a preventative effort in people whose genetic background makes their development of Alzheimer's virtually certain, and was thus started in patients very early.
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PR Newswire 02/12/2020 11:30
SAN DIEGO, Feb. 12, 2020 /PRNewswire/ -- Diagnomics Inc. (, a San Diego-based genetic testing company, announced today that they will be launching HealthLytix ( Alzheimer's risk assessment products on the GenoMatch.Me platform for employee wellness....
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Genetic Literacy Project 02/12/2020 07:02
Genetic mutations may provide natural defense against Alzheimer’s.
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