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FeedNavigator 01/18/2019 11:57
The purpose of our article is to assess the current understanding of Indian spice, curcumin, against amyloid-β (Aβ)-induced toxicity in Alzheimer's disease (AD) pathogenesis.
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Inspired also by many reports, underlining the presence of ubiquitin (Ub) in the amyloid plaques of AD brains, here we set out to test whether Ub may bind the Aβ peptide and have any effect on its clearance pathways.
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Fight Aging! 01/09/2019 06:11
The amyloid hypothesis has dominated the past twenty years of failed attempts to build therapies to treat Alzheimer's disease.
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BIOENGINEER.ORG 12/28/2018 10:56
Formation mechanism of the causative substances of Alzheimer’s disease revealed by molecular dynamics simulations and NMR experiments Credit: ExCELLS/IMS Many proteins aggregate at higher concentrations and form spherical substances called oligomers and acicular substances called amyloid fibrils.
Laboratory Equipment 12/21/2018 12:30
While blocking tau expression returned neural activity to normal levels in the mice that overexpressed that protein only, doxycycline treatment did not restore neural activity in animals expressing both pathologic proteins, even in mice too young to show neural damage.
More from Laboratory Equipment: 12/14/2018 00:18
Amyloid pathology involves a build-up of brain proteins known to cause Alzheimer's disease.
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PR Newswire 12/11/2018 03:05
Recognizing that the prevailing focus of Alzheimer's disease drug development on the amyloid cascade hypothesis has not generated new treatments, the Symposium brings together leaders from academic, research and corporate entities, in an effort to connect ideas and find alternative therapeutic targets.
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