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Comparing gut bacteria from lupus patients with bacteria from their healthy peers, scientists learned those with lupus had about five times more of the bacteria known as Ruminococcus gnavus.

Our analyses provide the first evidence that lupus is associated with intestinal outgrowths of RG, an obligate anaerobic species," the authors write.

More from DoctorsLounge:

Renal Transplant Improves Survival in ESRD Due to Lupus, 01/23/2019 13:00

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Many patients — reportedly 30% to 70% — with lupus nephritis, which is an inflammation of the kidneys caused by lupus, also have nephrotic syndrome.

More from BioNewsFeeds:

Dealing with the Emotional Part of My Lupus Diagnosis, 02/18/2019 10:00

It’s All or Nothing with Lupus, 02/15/2019 10:00

Looking into the Future with Lupus, 02/08/2019 10:00

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Gut microbiome imbalances may help diagnose, track lupus.

To find a transmissible agent in lupus pathogenesis, and to characterize the gut microbiome in systemic lupus erythematosus, with a special interest in lupus nephritis, Silverman and colleagues conducted a cross-sectional study of blood and fecal samples from patients at the New York University Langone Medical Center ...

More from Healio News:

Potential drug therapies persist amid 'lupus trial graveyard', 02/15/2019 20:18

Belimumab with standard care reduces organ damage in lupus, 01/28/2019 05:30

Renal transplantation improves survival in lupus nephritis, 01/21/2019 17:00

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Our study strongly suggests that in some patients bacterial imbalances may be driving lupus and its associated disease flares," says study senior investigator and immunologist Gregg Silverman, MD.

More from Medindia.com:

Study Shows How a Single Faulty Gene can Lead to Lupus, 12/19/2018 02:06

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About the Lupus Research Alliance The Lupus Research Alliance aims to transform treatment while advancing toward a cure by funding the most innovative lupus research in the world.

More from PR Newswire:

Bacteria in the Gut May be a Cause of Lupus, 02/19/2019 13:35

Lupus Foundation of America Reinvents its Online Home, 01/31/2019 15:45

Lupus Foundation of America Reinvents its Online Home, 01/31/2019 15:45

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Our study strongly suggests that in some patients bacterial imbalances may be driving lupus and its associated disease flares," says study senior investigator and immunologist Gregg Silverman, MD.

Condition : Systemic Lupus Erythematosus Interventions : Drug: Placebo; Drug: PF-06700841 15 mg; Drug: PF-06700841 30 mg; Drug: PF-06700841 45 mg Sponsor : Pfizer Not yet recruiting.

More from ClinicalTrials.gov:

A Study of Baricitinib in Participants With Systemic Lupus Erythematosus (SLE), 02/15/2019 12:00

Anti-ficolin-3 Antibodies in Lupus Nephritis, 02/15/2019 12:00

Autologous Hematopoietic Stem Cell Transplantation for Refractory Lupus Nephritis, 02/04/2019 10:04

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Washington: According to a new study conducted by scientists at NYU School of Medicine, systemic lupus erythematosus (SLE) is linked to an abnormal mix of bacteria in the gut. The disease is marked by the attack on joints, skin, and kidneys by the body’s immune system. The authors of the current study say their experiments are the first detailed evidence of a link between...

More from WN.com:

Volunteers sought for lupus prevention study, 02/15/2019 17:38

Idorsia initiates a multiple-dose efficacy and safety study with cenerimod for the treatment of systemic lupus erythematosus, 01/07/2019 01:47

Milestone in kidney health: Discovery of Ginsenoside M1 In the Treatment of Lupus Nephritis Awarded ..., 12/19/2018 18:11

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Contributors : Kit S Yeung ; Tsz L Lee ; Mo Y Mok ; Chun YuMak ; Wanling Yang ; Chun Y Chong ; Pui W Lee ; Hok K Ho ; Sanaa Choufani ; Chak S Lau ; Yu L Lau ; Rosanna Weksberg ; Hon Y Chung Series Type : Methylation profiling by genome tiling array Organism : Homo sapiens. Background: Patients with paediatric-onset systemic lupus erythematosus (SLE) often present with more severe clinical courses than adult-onset patients.

More from PubMed News (NIH):

GSE121751 Peptidylarginine deiminases 2 and 4 modulate innate and adaptive immune responses in TLR-7 dependent lupus, 01/16/2019 23:00

GSE124939 Hypersensitive interferon responses in lupus keratinocytes reveal key mechanistic determinants in cutaneous lupus, 01/14/2019 23:00

GSE120809 Transcriptome of discoid lupus erythematosus (DLE) skin, 01/01/2019 23:00

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No summary found

More from Annals of Internal Medicine:

Renal Transplantation and Survival Among Patients With Lupus Nephritis A Cohort Study, 02/18/2019 17:45

Kidney Transplantation in Lupus Nephritis: Can We Do Even Better?, 02/18/2019 17:45

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We recently demonstrated that aPL+ SLE patients had lower levels of circulating INF-α as compared to other lupus patients [ 47.

More from Arthritis Research & Therapy:

New-onset non-infectious pulmonary manifestations among patients with systemic lupus erythematosus in Sweden, 02/05/2019 19:00

Endothelial activation and injury by microparticles in patients with systemic lupus erythematosus and rheumatoid arthritis, 01/22/2019 19:00

Vitamin D protects podocytes from autoantibodies induced injury in lupus nephritis by reducing aberrant autophagy, 01/10/2019 19:00

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This study aimed to identify the long-term clinical outcomes and prognostic factors of patients with systemic lupus erythematosus (SLE)-associated pulmonary arterial hypertension (PAH) confirmed by right heart catheterisation. A multicentre prospective cohort of SLE-associated PAH was established.

More from European Respiratory Journal:

Long-Term Prognosis of Patients with Systemic Lupus Erythematosus-Associated Pulmonary Arterial Hypertension: CSTAR-PAH Cohort Study, 01/11/2019 06:03

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We also find that pulmonary manifestations of lupus are a source of substantial and potentially serious disease activity," he told MedPage Today.

More from MedPageToday.com:

Nephrotic Syndrome: A Hindrance to Lupus Treatment?, 02/06/2019 13:00

In 2019, What Are the Major Challenges in Lupus?, 01/21/2019 12:00

IgE: A Novel Target in Lupus?, 01/10/2019 12:00

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The experts will present the natural history, the symptoms and current prevalence of lupus.

More from GlobeNewswire:

Neovacs announces its clinical advisory board meeting to design the Phase III Study for IFNalpha Kinoide in lupus - Paris February 11th, 01/31/2019 11:45

Neovacs and Centurion Pharma continue their collaboration in Lupus based on the results of the Phase IIb trial with IFNalpha Kinoid, 12/11/2018 01:31

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Researchers reveal how receptor TLR-9 protects against lupus.

Treatment success in systemic lupus erythematosus-associated pulmonary arterial hypertension, as defined by the European Society of Cardiology and the European Respiratory Society, is associated with long-term survival and supports a treat-to-target strategy.

Survival among patients with lupus nephritis (LN) is associated with achievement of complete response (CR) to induction therapy at 12 months, new data suggest.

More from Renal & Urology News Hypertension:

Kidney Transplantation Ups Survival in Lupus Nephritis Cases, 01/24/2019 07:00

Urine Immunoassay Identifies Novel Lupus Nephritis Biomarkers, 01/16/2019 09:00

Similar Long-Term Outcomes in Early- vs Late-Onset Lupus Nephritis, 12/18/2018 06:30

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J Oral Maxillofac Surg. 2019 Jan 5. pii: S0278-2391(18)31405-8. doi: 10.1016/j.joms.2018.12.035. [Epub ahead of print]

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