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American Diabetes Journals 03/20/2019 15:00
OBJECTIVE. To evaluate the safety and efficacy of IONIS-GCGR Rx , a 2'- O -methoxyethyl antisense oligonucleotide targeting the glucagon receptor (GCGR), and the underlying mechanism of liver transaminase increases in patients with type 2 diabetes on stable metformin therapy. RESEARCH DESIGN AND METHODS. In three phase 2, randomized, double-blind studies, patients with type 2 diabetes on metformin received weekly subcutaneous injections of IONIS-GCGR Rx (50–200 mg) or placebo for 13 or 26 weeks. RESULTS. Significant reductions in HbA 1c were observed after IONIS-GCGR Rx treatment versus placebo at week 14 (–2.0% 200 mg, –1.4% 100 mg, –0.3% placebo; P < 0.001) or week 27 (–1.6% 75 mg, –0.9% 50 mg, –0.2% placebo; P < 0.001).
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FeedNavigator 03/20/2019 12:47
Chronic disease management platform Hello Heart will now integrate with LifeScan OneTouch meters as part of its program for diabetes management.
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Healio News 03/20/2019 11:30
Potential diabetic retinopathy treatment fails to meet phase 2b study endpoint.
More from Healio News: 03/20/2019 08:24
Another study on diabetic rats revealed that drinking amla juice may help treat certain health problems widespread in people with type 1 diabetes mellitus.
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Invokana is indicated for the treatment of adults with insufficiently controlled T2DM as an adjunct to diet and exercise, as monotherapy when metformin is considered inappropriate due to intolerance or contraindications and in addition to other medicinal products for the treatment of diabetes ...
More from Global Banking & Finance Review: 03/20/2019 01:53
Artificial intelligence in healthcare uses an algorithms and software to approximate human cognition in analysis of complex medical data.
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Becker's Hospital Review 03/19/2019 17:06
One Drop, a digital health company focused on diabetes care management, will offer its diabetes therapy services as part of Amazon's at-home medical devices brand Choice.
More from Becker's Hospital Review: 03/19/2019 10:26
Conditions : Diabetic Foot; Diabetic Foot Ulcer; Ulcer Foot Interventions : Other: Human Autologous Homologous Skin Construct; Other: Additional Outer Dressing Applicaiton; Other: Offloading; Other: Fibracol Wound Dressing Sponsors : Professional Education and Research Institute; Polarity TE Recruiting.
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Top Class Actions 03/19/2019 07:00
Because these diabetes drugs work through kidney stimulation, a patient taking one of these drugs may feel the urge to urinate more frequently.
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Business Wire 03/18/2019 09:00
Likewise, Juan Carlos’ addition to the team provides guidance and experience to advance the company’s clinical pipeline as we develop novel, disease-modifying therapies for metabolic diseases, including type 2 diabetes and NAFLD/NASH.
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ENDPOINTS 03/18/2019 08:46
Roughly two years after raising $40 million in a private placement, Aerpio Pharmaceuticals’ lead experimental eye drug has hit a roadblock after failing a mid-stage study in patients with non-proliferative diabetic retinopathy (NPDR) — the earliest stage of diabetic eye disease, which occurs when high blood sugar levels cause damage to blood vessels in the retina ...
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Lifeboat News: The Blog 03/16/2019 06:22
It is often not the lack of a cure, but the lack of will. Many great strides have been made with diabetes, when people stopped trying to develop medicines, and instead focused on how to enable the body to produce insulin. Restoration of insulin independence and normoglycemia has been the overarching goal in diabetes research […]
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Diabetes In Control News 03/15/2019 20:09
Conclusions from an analysis assessing over 20,000 people with diabetes in the REACH (Reduction of Atherothrombosis for Continued Health) registry showed a 31% decrease in heart failure mortality rate in patients who were treated with metformin in comparison with those patients who were not on metformin ...
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