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Inducers of CYP3A4 The concomitant use of PERCOCET and CYP3A4 inducers, such as rifampin, carbamazepine, and phenytoin, can decrease the plasma concentration of oxycodone [see CLINICAL PHARMACOLOGY ], resulting in decreased efficacy or onset of a withdrawal syndrome in patients who have developed physical dependence to PERCOCET [see WARNINGS ...
More from National Library of Medicine - DailyMed Drug Label Updates (NLM):
ALEXANDRIA, Va. – A Fairfax medical doctor was sentenced today to 10 years in prison and fined $30,000 for illegally diverting Adderall and oxycodone to six different patients, including a patient who suffered from opioid addiction and later died of a drug overdose.
More from Federal Bureau of Investigation (FBI): 05/22/2020 20:26
Condition : Post-operative Pain Control Intervention : Drug: acetaminophen/codeine vs acetaminophen/oxycodone Sponsor : 59th Medical Wing Completed.
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Mini-Sentinel 04/30/2020
The objective of this manuscript was to assess the relative frequency with which oxymorphone and oxycodone (a CYP3A-metabolized opioid analgesic) were each prescribed to patients concomitantly receiving CYP3A-modifying drugs (i.e., inducers and inhibitors) to characterize opioid-prescribing patterns in patients at risk for CYP3A-related drug interactions.
... in April 2020 NBER Program(s):Economics of Aging, Health Economics Recent evidence suggests that the short-term transition of the opioid crisis from prescription opioids to heroin can be attributed to the reformulation of OxyContin, which substantially reduced access to abusable prescription opioids.

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