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Deregulated activity of the LATS tumor suppressors has broad implications on cellular and tissue homeostasis. We examined the consequences of downregulation of either LATS1 or LATS2 in breast cancer. Consistent with their proposed tumor-suppressive roles, expression of both paralogs is significantly downregulated in human breast cancer, and loss of either paralog accelerated mammary tumorigenesis in mice. However, each paralog had a distinct impact on breast cancer. LATS2 depletion in luminal B tumors resulted in metabolic rewiring, with increased glycolysis and reduced PPARg signaling. Furthermore, pharmacologic activation of PPARg elicited LATS2-dependent death in luminal B-derived cells. In contrast, LATS1 depletion augmented cancer cell.
In agreement with this, genomic profiling of a large (n = 1,501) cohort of endocrine therapy–naïve versus endocrine therapy–exposed ER+ breast cancers did not show any evidence of AKT1 mutations being associated with resistance to hormonal therapy (15.
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Healio News 07/30/2020 09:37
The researchers noted that establishing models for basic research into mechanisms of hypercoagulability in COVID-19, as well as the intersecting effects of COVID-19 and estrogen therapy or pregnancy, will require innovative, novel animal and tissue models.
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ClinicalTrials.gov 07/28/2020 06:52
Condition : Prostate Cancer Interventions : Radiation: SBRT; Drug: Androgen deprivation therapy (ADT) Sponsor : VA Greater Los Angeles Healthcare System Active, not recruiting.
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Business Wire 07/20/2020 08:00
Targeting MET and AXL overcomes resistance to sunitinib therapy in renal cell carcinoma.
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Secondly, 34 of the women were taking menopausal hormone therapy, and they tended to have more Lactobacillus-type bacteria in their urine, which may imply that the oestrogen in [HRT] supports the growth of Lactobacillus in the urogenital tract.
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