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The subcellular localization of NR1H3 in the endometrial carcinoma cell line Ishikawa was determined by immunofluorescence.
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WN.com 01/16/2019 21:02
Every year, about 63,000 women are diagnosed with uterine cancer, according the American Cancer Society.
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News-Medical.net 01/16/2019 02:43
Led by researchers at Baylor College of Medicine, the team of scientists found that the Transforming Growth Factor beta (TGF-beta) signaling pathway in uterine cells protects against the disease by suppressing the overgrowth and transformation into cancer cells of the endometrium, the membrane lining the inside of the uterus.
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ClinicalTrials.gov 01/15/2019 10:59
Condition : Endometrial Cancer Interventions : Procedure: endometrial cancer radical surgery; Procedure: fertility-sparing surgery; Procedure: ovarian preservation surgery Sponsors : Min Wang; First Hospital of China Medical University Not yet recruiting.
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Purpose:. Amplification of PIK3CA , encoding the PI3K catalytic subunit alpha, is common in uterine corpus endometrial carcinoma (UCEC) and linked to an aggressive phenotype. However, it is unclear whether PIK3CA amplification acts via PI3K activation. We investigated the association between PIK3CA amplification, markers of PI3K activity, and prognosis in a large cohort of UCEC specimens. Experimental Design:. UCECs from 591 clinically annotated patients including 83 tumors with matching metastasis ( n = 188) were analyzed by FISH to determine PIK3CA copy-number status. These data were integrated with mRNA and protein expression and clinicopathologic data. Results were verified in The Cancer Genome Atlas dataset. Results:. PIK3CA amplification.
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Emerging evidence indicates that adipose stromal cells (ASC) are recruited to enhance cancer development. In this study, we examined the role these adipocyte progenitors play relating to intercellular communication in obesity-associated endometrial cancer. This is particularly relevant given that gap junctions have been implicated in tumor suppression. Examining the effects of ASCs on the transcriptome of endometrial epithelial cells (EEC) in an in vitro coculture system revealed transcriptional repression of GJA1 (encoding the gap junction protein Cx43) and other genes related to intercellular communication. This repression was recapitulated in an obesity mouse model of endometrial cancer. Furthermore, inhibition of plasminogen activator i.
PubMed News (NIH) 12/24/2018 23:00
Human endometrial cancer stem spheroid cells from three patients were sorted into ALDH-high and ALDH-low cells using the FACS Aria II Cell Sorter.
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GlobeNewswire 12/21/2018 01:00
Through strategic in-licensing and disciplined drug development, ObsEva has established a late-stage clinical pipeline with development programs focused on treating endometriosis, uterine fibroids, preterm labor and improving IVF outcomes.
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