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ClinicalTrials.gov 02/20/2020 08:24
By treating an obese patient's endometrial cancer, one cause of death may be prevented but an important opportunity is missed to improve overall survival after cancer treatment.
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Individualized Medicine blog 02/20/2020 07:00
Post-menopausal women would go to the doctor because of bleeding, and they would get a biopsy of their uterus and the biopsy was benign, and then sometime down the road they developed endometrial cancer.
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Cancer Cell International 02/18/2020 19:00
Endometrial cancer (EC) is one kind of women cancers. Bioinformatic technology could screen out relative genes which made targeted therapy becoming conventionalized.
More from Cancer Cell International:
LncRNA DCST1-AS1 Was Upregulated in Endometrial Carcinoma and May Sponge miR-92a-3p to Upregulate Notch1.
More from International Journal of COPD:
News-Medical.net 02/16/2020 17:45
A new study reveals the molecular steps that bring about endometrial cancer, commonly known as uterine cancer, which is the sixth most common cancer in women across the globe.
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Cervical MMMTs, compared to their counterparts in the corpus, are more commonly confined to the uterus at presentation, have a non-glandular epithelial component, and potentially have a better prognosis, whereas carcinosarcoma of the uterine corpus almost always has adenocarcinomatous component [16.
The research team previously found microbiome differences between patients with and without endometrial cancer in a uterine microbiome study published in 2017 that led to the development of a vaginal swab screening methodology used for endometrial cancer.
More from Medical Xpress - Obstetrics & Gynaecology:
Human endometrial cancer and normal endometrial tissues were acquired from patients at Wuhan Union Hospital and UBE2C expression was detected by Western blotting and qRT-PCR.
More from Molecular Cancer Research - Recent Issues (abstracts):
Purpose:. Treatment for patients with recurrent endometrioid endometrial cancer (EEC) are limited as paclitaxel is the only second-line chemotherapy with a response rate >13%. Targeting PIK3/mTOR in combination with hormonal therapy has shown promise. The addition of metformin may enhance this response. We conducted a phase II study evaluating everolimus, letrozole, and metformin in advanced/recurrent EEC. Patients and Methods:. A Simon two-stage design was employed. Women with ≤2 prior chemotherapy regimens for recurrence were eligible. Pretreatment biopsy was required, followed by everolimus 10 mg orally, letrozole 2.5 mg orally, and metformin 500 mg orally twice a day on a 4-week cycle. The primary endpoint was clinical benefit (CB), defin.
More from Clinical Cancer Research - Recent Issues (abstracts):
Cancer Network 01/26/2020
This phase II study demonstrated that to enhance efficacy, future studies evaluating the combination of PI3K pathway inhibitors with a ketogenic diet or SGLT2 inhibitors in PI3K pathway altered endometrial carcinomas and carcinosarcomas are both warranted and currently planned.
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