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WN.com 03/19/2019 15:12
GSK reports positive data from trial of endometrial cancer drug.
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FeedNavigator 03/17/2019 20:29
Based on the presence of endometrial hyperplasia (EH) or cancer (EC), the women were divided into cases (EH/EC) and controls (no EH/EC.
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ClinicalTrials.gov 03/15/2019 11:38
Conditions : Endometrial Carcinoma; Lymphadenectomy Intervention : Procedure: Pelvic and Peritoneal Lymphadenectomy Sponsor : Second Affiliated Hospital of Wenzhou Medical University Not yet recruiting.
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Healio News 03/07/2019 15:09
Regardless, Jørgensen and colleagues have demonstrated that increasing the rate of minimally invasive hysterectomy can improve outcomes for women undergoing hysterectomy for early-stage endometrial cancer.
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The molecular events driving low-grade endometrioid endometrial carcinoma (LGEC) development—like in many cancers—are incompletely understood. Hence, here we performed multiregion, comprehensive somatic molecular profiling of routinely processed formalin-fixed, paraffin-embedded (FFPE) material from 13 cases of LGEC totaling 64 minute, spatially defined cell populations ranging from presumed precursor lesions through invasive LGEC. Shared driving PTEN, PIK3R1 , or PIK3CA mutations support clonal origin of the samples in each case, except for two cases with two clonally distinct neoplastic populations, consistent with unexpected multiclonality in LGEC development. Although substantial heterogeneity in driving somatic alterations was present

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