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News-Medical.net 07/18/2019 09:34
According to a new report by Cancer Research UK, the incidence of skin cancer has “soared” over the last ten years, with men and younger adults experiencing the greatest leap in cases of melanoma.
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Business Wire 07/18/2019 07:00
Research generated from the registry will examine risk factors, genetics, epidemiology, treatment cost-effectiveness and real-world outcomes from a database of patients with uveal melanoma.
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inews.co.uk (UK) 07/17/2019 19:01
Cancer Research UK found rates of melanoma – the most deadly type of skin cancer – rose dramatically between 2004-2006 and 2014-2016, the most recent figures available.
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Skin cancer rates have soared by 45% in 10 years 'because of package holidays and cheap flights'.
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J Oral Maxillofac Surg. 2019 Jun 21. pii: S0278-2391(19)30636-6. doi: 10.1016/j.joms.2019.06.007. [Epub ahead of print]
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PR Newswire 07/17/2019 07:30
When diagnosed and treated at an early stage, it has a high cure rate, however patients with later stages of the disease carry a high risk for melanoma recurrence because some melanoma cells can remain in the body, even after surgery.
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ClinicalTrials.gov 07/16/2019 06:54
Condition : Cutaneous Melanoma Intervention : Drug: Atezolizumab Sponsors : Ashley Holder, MD; Genentech, Inc. Not yet recruiting.
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PubMed News (NIH) 07/16/2019
These findings suggest a role of the Rho/MRTF-pathway in high intrinsic trametinib resistance to a subset of NRAS mutant melanoma cell lines and highlights the potential of concurrently targeting the Rho/MRTF-pathway and MEK in NRAS mutant melanomas.
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Healio News 07/15/2019 16:00
Survival advantage suggested in responders to immunotherapy for uveal melanoma.
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GlobeNewswire 07/15/2019 06:00
At 13.4-month median follow-up in 34 patients with metastatic melanoma, median PFS had not yet been reached.
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Purpose:. Immune checkpoint blockade (ICB) therapy induces durable tumor regressions in a minority of patients with cancer. In this study, we aimed to identify kinase inhibitors that were capable of increasing the antimelanoma immunity. Experimental Design:. Flow cytometry–based screening was performed to identify kinase inhibitors that can block the IFN-induced PD-L1 expression in melanoma cells. The pharmacologic activities of regorafenib alone or in combination with immunotherapy in vitro and in vivo were determined. The mechanisms of regorafenib were explored and analyzed in melanoma patients treated with or without anti–PD-1 using The Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) datasets. Results:. Through screening of.
More from Clinical Cancer Research - Recent Issues (abstracts):
In this Mayo Clinic Radio Health Minute, Dr. Alison Bruce, a Mayo Clinic dermatologist, tells us what to be on the lookout for when it comes to skin cancer. To listen, click the link below. Raising your skin cancer IQ.
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