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Business Wire 08/05/2020 08:00
NEW YORK--(BUSINESS WIRE)--Pfizer Inc. (NYSE:PFE) today announced that the Phase 3 CROWN study of LORBRENA® (lorlatinib) in people with previously untreated advanced anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) met its primary endpoint by demonstrating significantly improved progression-free survival (PFS), as compared to XALKORI® (crizotinib).
More from Business Wire: 08/05/2020 07:27
Condition : Carcinoma, Non-Small Cell Lung Intervention : Drug: Durvalumab Sponsors : Georgetown University; AstraZeneca Not yet recruiting.
More from 08/05/2020 00:21
Researchers use microscopy technique to predict the course of lung cancer.
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Serum Exosomal miR-1290 is a Potential Biomarker for Lung Adenocarcinoma.
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Medical Xpress - Cancer News 08/04/2020 14:11
Scientists accelerate progress in preventing drug resistance in lung and pancreas cancers.
More from Medical Xpress - Cancer News:
Background: Non-small cell lung cancer (NSCLC) is a molecularly heterogeneous disease with a high propensity for drug resistance and metastasis. AXL, a member of the Tyro3-AXL-Mer (TAM) family of receptor tyrosine kinases, is a central regulator of epithelial-to-mesenchymal transition (EMT) and enables tumor cells to invade and acquire drug resistance. AXL is overexpressed in NSCLC and its expression correlates positively with tumor invasion, drug resistance, and negatively predicts overall survival. We mechanistically interrogated the effects of the AXL inhibitor, TP-0903, on EMT in NSCLC cells using transcriptomic and proteomic profiling. Methods: Atomic force microscopy, Western blot analysis, RNA sequencing, and mass cytometry (CyTOF) w.
More from Molecular Cancer Research - Recent Issues (abstracts):
PubMed News (NIH) 08/04/2020
Here, we show that in lung cancer, interaction between paxillin (PXN) and integrin b4 (ITGB4), components of the focal adhesion (FA) complex, contributes to cisplatin resistance.
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Healio News 08/03/2020 09:51
Back to Healio People with interstitial lung abnormalities have an increased risk for lung cancer and lung cancer mortality, but not other cancers, according to a study published in the European Respiratory Journal.
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Lung Cancer Blog 08/03/2020 04:11
Lung cancer continues to be one of the most common cancers worldwide and claims even more lives than breast, colon and prostate cancer yearly.
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Whether DDR alterations are associated with clinical outcomes to programmed death ligand 1 [PD-(L)1] blockade in non–small cell lung cancer (NSCLC) is unknown.
More from Clinical Cancer Research - Recent Issues (abstracts):
Background:. IFN is a pleiotropic cytokine that plays critical immunomodulatory roles in intercellular communication in innate and adaptive immune responses. Despite recognition of IFN signaling effects on host defense against viral infection and its utility in immunotherapy and tumor progression, the roles of genetic variants of the IFN signaling pathway genes in survival of patients with cancer remain unknown. Methods:. We used a discovery genotyping dataset from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial ( n = 1,185) and a replication genotyping dataset from the Harvard Lung Cancer Susceptibility Study ( n = 984) to evaluate associations between 14,553 genetic variants in 150 IFN pathway genes and survival of non–sma.
More from Cancer Epidemiology, Biomarkers & Prevention Recent Issues (abstracts): 08/03/2020 01:36
Non-small cell lung cancer accounts for approximately 85% of all lung cancers.
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GlobeNewswire 08/03/2020 01:00
Our goal is to provide an effective treatment option for every person diagnosed with lung cancer.
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