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FeedNavigator (EU) 08/04/2020 09:21
Associating cancer, kidney disease, and stroke with COVID-19 severity should be carefully interpreted.
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Business Wire 08/04/2020 07:00
This TCR therapy is currently in a Phase 1 trial at NHLBI for the treatment of metastatic clear cell Renal Cell Carcinoma (ccRCC) that failed an angiogenic inhibitor and a checkpoint inhibitor.
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San Diego, CA Alterations of the Hippo signaling pathway have been found in patients with sarcomatoid renal cell carcinoma, a highly aggressive kidney disease with rapid progression and poor prognosis.
More from Molecular Cancer Research - Recent Issues (abstracts):
PubMed News (NIH) 08/01/2020
By performing transcriptomics analyses from TRACK versus wild type (WT) kidneys after dietary vitamin A deprivation, we show that both vitamin A deficiency (VAD) and expression of constitutively active HIF1α intensify the MSR, redirect amino acids to one carbon metabolism, and facilitate the biosynthesis of reduced ...
More from PubMed News (NIH): 07/31/2020 07:58
Evidence indicates to worse outcomes in patients with pre-existing diseases, such as diabetes, arterial hypertension, heart disease, pneumopathies, chronic kidney disease, and immunodeficiencies.
More from 07/31/2020 05:11
Professor Amit Bahl, a consultant medical oncologist specialised in renal cell carcinoma, said: “This positive recommendation from NICE provides patients with advanced Renal Cancer an effective and well tolerated treatment option with proven benefits in progression free survival and objective response rates from a randomised Phase 3 ...
PharmaTimes 07/31/2020 02:50
This positive recommendation from NICE provides patients with advanced renal cancer an effective and well tolerated treatment option with proven benefits in progression free survival and objective response rates from a randomised Phase III trial,” said Professor Amit Bahl, a consultant medical oncologist specialised in renal ...
Healio News 07/29/2020 11:09
Inactivation of von-Hippel-Lindau occurs in more than 90% of clear cell renal cell carcinoma tumors.
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Registrations of Patients with Renal Cell Carcinoma in the Nationwide Danish Renal Cancer Database versus the Danish Cancer Registry: Data Quality, Completeness and Survival (DaRenCa Study-3)
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Cancer Cell International 07/23/2020 20:00
The fluorescence signal intensity in the renal region of nude mice was measured weekly by in vivo optical imaging system (IVIS Spectrum, Caliper, USA) [16.
More from Cancer Cell International: 07/22/2020 20:41
Experts use genomic analysis tools to create personalized treatment for kidney cancer patients.
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Purpose:. Translocation renal cell carcinoma (tRCC) is a rare, aggressive renal cell carcinoma (RCC) subtype. There is currently limited understanding on the role of molecular alterations in the pathogenesis and progression of these tumors. We investigated the association between somatic alterations and clinical outcomes in two independent cohorts profiled using DNA sequencing. Experimental Design:. Twenty-two tRCCs underwent targeted sequencing [Memorial Sloan Kettering Cancer Center (MSK)-IMPACT]; a subset was profiled using exome-sequencing and combined with exome data from The Cancer Genome Atlas (TCGA) for analysis. The prognostic value of specific somatic aberrations, tumor mutation burden (TMB), and fraction of copy-number–altered geno.
More from Clinical Cancer Research - Recent Issues (abstracts):
Importantly, Rac1 controls paracrine signaling of angiogenic factors including VEGF from renal carcinoma cells to surrounding blood vessels.
More from Molecular Cancer Therapeutics - Recent Issues (abstracts):
We compared the prevalence and adjusted prevalence ratios (aPR) of cigarette smoking (current vs. never, former vs. never) among individuals diagnosed between 2011 and 2016 with clear cell RCC, papillary RCC, chromophobe RCC, renal collecting duct/medullary carcinoma, cyst-associated RCC, and unclassified RCC.
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