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Your search is now limited to «Breast Cancer» expert search. 08/05/2020 07:26
Condition : HER2-negative Breast Cancer Interventions : Drug: AT regimen; Drug: TP regimen Sponsor : Sichuan Provincial People's Hospital Not yet recruiting.
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Korean Biomedical Review 08/05/2020 04:01
Song added that Pfizer Korea would continue to make efforts to present improved treatment options to patients and medical staff and bring meaningful changes to patients' lives through innovative treatments for breast cancer and various carcinomas.
More from Korean Biomedical Review: 08/05/2020 02:37
However, despite the possibilities opened to medical specialists by MRI, this method is rarely used to produce breast scans because apart from the scanner itself, this procedure requires additional specialized equipment.
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Novel technology tests the presence of thin membrane protrusions on breast cancer cells.
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lncRNA NEAT1 Facilitates Cell Proliferation, Invasion and Migration by Regulating CBX7 and RTCB in Breast Cancer [Retraction]
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HER2‐positive breast cancer represents aggressive subtype typical of poor response to standard chemotherapy.
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Healio News 08/04/2020 11:42
Back to Healio Pregnancy after breast cancer appeared safe for women with germline BRCA mutations and did not appear to worsen maternal prognosis, according to results of a retrospective study published in Journal of Clinical Oncology.
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Business Wire 08/04/2020 09:00
The pivotal study evaluated the safety and efficacy of pegloprastide in women with primary, nonrecurrent breast cancer undergoing surgery.
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The molecular processes fueling disease progression have been delineated in recent studies and the clonal composition of breast cancer samples can be examined in detail.
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The Crk adaptor protein, a critical modifier of multiple signaling pathways, is overexpressed in many cancers where it contributes to tumor progression and metastasis. Recently, we have shown that Crk interacts with the peptidyl prolyl cis-trans isomerase, Cyclophilin A (CypA; PP1A) via a G 219 P 220 Y 221 (GPY) motif in the carboxyl-terminal linker region of Crk, thereby delaying pY221 phosphorylation and preventing downregulation of Crk signaling. Here, we investigate the physiologic significance of the CypA/Crk interaction and query whether CypA inhibition affects Crk signaling in vitro and in vivo . We show that CypA, when induced under conditions of hypoxia, regulates Crk pY221 phosphorylation and signaling in cancer cell lines. Using
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HER2-positive breast cancer is currently managed with chemotherapy in combination with specific anti-HER2 therapies, including trastuzumab. However, a high percentage of patients with HER2-positive tumors do not respond to trastuzumab (primary resistance) or either recur (acquired resistance), mostly due to molecular alterations in the tumor that are either unknown or undetermined in clinical practice. Those alterations may cause the tumor to be refractory to treatment with trastuzumab, promoting tumor proliferation and metastasis. Using continued exposure of a HER2-positive cell line to trastuzumab, we generated a model of acquired resistance characterized by increased expression of several cytokines. Differential gene expression analysis
The abundance and location of G-quadruplexes in these biopsies gives us a clue to their importance in cancer biology and to the heterogeneity of these breast cancers," added Dr. Robert Hänsel-Hertsch who is now at the Center for Molecular Medicine Cologne, University of Cologne, and is first author on the publication.
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Benzinga 08/03/2020 10:25
Her services include the evaluation of both benign conditions and breast cancer.
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Medical Xpress - Cancer News 08/03/2020 07:30
Breast cancers, inclusive of ductal carcinoma in situ, were identified from the completed BMTSS survey.
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Translational Relevance Early identification of the AKT1E17K genomic biomarker, coupled with a novel targeted and nonmyeloablative agent, could enhance treatment options in AKT1E17K-mutant estrogen receptor–positive (ER+) metastatic breast cancer.
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PubMed News (NIH) 08/03/2020
Contributors : Kazuhiro Ikeda ; Kuniko Horie-Inoue ; Satoshi Inoue Series Type : Expression profiling by array Organism : Homo sapiens. To examine the role of long non-coding RNA TMPO-AS1 in breast cancer, MDA-MB-231 cells were treated with siRNAs targeting TMPO-AS1 (siTMPO-AS1) or control siRNA (siControl).
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FeedNavigator (EU) 08/01/2020 08:24
These data reveal that a human exogenous betaretrovirus similar to MMTV has existed at least since 4,500 years ago and indirectly support the hypothesis that it could play a role in human breast cancer.
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