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PubMed News (NIH) 02/17/2020 23:00
Contributor : Serge McGraw Series Type : Methylation profiling by high throughput sequencing Organism : Mus musculus. In early embryos, DNA methylation is remodelled to initiate the developmental program. For mostly unknown reasons, methylation marks are acquired unequally between embryonic and placental cells. To better understand this, we generated high-resolution maps of DNA methylation in mouse mid-gestation (E10.5) embryo and placenta. We uncovered specific subtypes of differentially methylated regions (DMRs) that contribute directly to the developmental asymmetry existing between mid-gestation embryo and placenta. We show that the asymmetry between embryonic and placental DNA methylation patterns occurs rapidly during the acquisition o.
PubMed News (NIH) 02/16/2020 23:00
Contributor : Jacob Gratten Series Type : Methylation profiling by genome tiling array Organism : Homo sapiens. Genome wide DNA methylation association analysis of Parkinson's disease and control samples. The Illumina Infinium 450k Human DNA methylation Beadchip was used to obtain DNA methylation profiles across approximately 450,000 CpGs in blood samples. Samples included 1001 Parkinson's disease cases and 973 controls.
PubMed News (NIH) 02/16/2020 23:00
Contributors : Chen Jian ; Schedl Tim Series Type : Genome binding/occupancy profiling by high throughput sequencing Organism : Caenorhabditis elegans. We report the application of conventional ChIP-seq analysis for LAG-1 chromatin state in germline. We identified 137 genes putatively regulated by LAG-1 that's overlapped by three independent biological replicates. These genes included previously known targets lst-1, sygl-1, and mir-61/250.
PubMed News (NIH) 02/16/2020 23:00
Status Public on Feb 17, 2020 Title Magnitude of modulation of gene expression in aneuploid maize depends on the extent of genomic imbalance Organism Zea mays Experiment type Expression profiling by high throughput sequencing Other Summary Aneuploidy has profound effects on an organism, typically more so than polyploidy, and the basis of this contrast is not fully understood ...

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