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Pharmafile 02/14/2020 07:40
The coronavirus continues to dominate the news, with the disease finally getting treated. In America, a patient has been successfully treated with an Ebola drug from Gilead. This drug is also being used in China on patients with mass production set to start soon. Pharmaceutical companies have also seen some staff shakeups, with GlaxoSmithKline set to cut 720 jobs in Belgium while Sanofi has axed five members of its executive committee.
Pharmafile 02/14/2020 07:34
The incidence of mumps in the England has reached its highest level in 10 years, prompting warnings from health officials for the public to ensure they and their children receive the MMR (measles, mumps, rubella) vaccine in the interest of public health. Last year there were 5,042 recorded cases of mumps in England, a staggering four-fold rise on the incidence of the disease in 2018.
Pharmafile 02/14/2020 07:12
The global drug market is facing issues over production due to the coronavirus ravaging the supply line from China. In the United States, the White House Trade Advisor, Peter Navarro, has called on the country to reduced pharmaceutical imports from China. In efforts to contain the virus, China has halted work in many factories including ones that manufacture products for the pharmaceutical industry.
Pharmafile 02/14/2020 05:21
The FDA has requested that Eisai withdraw its weight loss drug Belviq (lorcaserin) and Belviq XR from the US market after clinical trial data indicated that those receiving the drug exhibited an increased incidence of cancer. The findings arose from a review of trial results last month, from which it was determined that the "potential risk of cancer associated with the drug outweighs the benefit of treatment," according to the FDA's Center for Drug Evaluation and Research, Janet Woodcock.
Pharmafile 02/13/2020 08:00
Sanofi has announced it will cull its executive committee under plans orchestrated by new Chief Executive Officer Paul Hudson, who joined the company in September last year. The reshuffle was announced during Sanofi’s fourth-quarter earnings call. The intention is to streamline the committee’s operations and cut down on internal bureaucracy. As Hudson said, the move should help “allocate more of our central expertise into our business units and increase the accountability.”
Pharmafile 02/13/2020 07:17
Eli Lilly and Incyte have pulled back the curtain on Phase 3 data on their oral selective JAK inhibitor baricitinib as a treatment for moderate to severe atopic dermatitis in adult patients. The findings showed that a clinically significant proportion of the trial’s participants taking either 1mg and 2mg doses of baricitinib achieved a change of at least 75% according to the Eczema Area and Severity Index (EASI) after 16 weeks of treatment, meeting the primary endpoint of the study.
Pharmafile 02/13/2020 06:21
The coronavirus outbreak reached its deadliest day since it began in December. Roughly 242 deaths have been reported in Hubei province on Wednesday. This is partly due to the region starting to use a broader definition to diagnose people, but this is only being used in Hubei so far. This new definition includes those showing symptoms, and having a CT scan showing an infected lung, rather than relying only on the standard nucleic acid tests. Of the new 242 deaths, 135 of these clinically diagnosed cases.
Pharmafile 02/12/2020 07:58
The widespread addiction to extremely potent, legal painkillers has decimated the lives of millions across the United States. Overdoses from opioids have surpassed car crashes and gun violence as the leading cause of death in Americans under the age of 55. The epidemic has killed nearly 400,000 people since 2000 – more people than HIV at the peak of that disease – while its economic cost has been placed between $50 billion and $1 trillion.
Pharmafile 02/12/2020 07:57
Researchers at the Institute of Cancer Research have discovered that a small RNA molecule known as microRNA gene MIR1249 contributes to the chemotherapy-resistant nature of some bile duct tumours, potentially paving the way for more effective cancer-fighting drugs. The body’s WNT signalling network is partly responsible for the regulation of stem cells, but the MIR1249 gene is able, according to the researchers, to "rewire" this network, enabling cancer cells to co-opt the resilient, self-regenerating properties of stem cells, allowing them to survive bouts of chemotherapy.
Pharmafile 02/12/2020 07:35
A new study has given further evidence that rosiglitazone can contribute to risk of heart problems and heart failure. The British Medical Journal study was led by the Yale School of Public Health. It analysed the results of more than 130 trials involving over 48,000 adult patients that compared rosiglitazone with any control for at least 24 weeks. Individual Patient Data (IPD) was available for 33 trials, included 21156 patients. The remaining trials only had summary level data available.
Pharmafile 02/12/2020 07:05
Men are living seven years in poor health while women are living nearly ten years, according to a new report. The research titled ‘The Health of the Nation: A Strategy for Healthier Longer Lives’, has been written by the All-Party Parliamentary Group (APPG) for longevity based on new NHS data. It found that men on average were being diagnosed with their first long-term medical condition at 56 and women at 55.
Pharmafile 02/12/2020 05:10
A drugmaker in China said it has started mass producing Gilead Sciences Ebola drug that has the potential to fight the coronavirus. It will be developed by BrightGene Bio-Medical Technology. They said in a statement, filed to the Shanghai Stock Exchange,it has the technology to synthesize the active pharmaceutical ingredients of remdesivir, Gilead’s drug that is a leading candidate to treat the coronavirus.
Pharmafile 02/11/2020 07:33
In another blow to Alzheimer’s research, it has emerged that a study investigating Eli Lilly’s solanezumab in the treatment of early-onset Alzheimer’s disease failed to meet its primary endpoint. The news follows Roche and Genentech’s announcement that : autosomal dominant Alzheimer’s, a hereditary, early-onset form of the disease which accounts for less than 1% of all ca.
Pharmafile 02/11/2020 07:14
The Scottish Medicines Consortium (SMC) has approved targeted combination therapy for the treatment of adult patient with unresectable or metastatic melanoma with a BRAF V600 mutation. The approval means that encorafenib plus binimetinibi will be used as the first and only targeted therapy available in Scotland for both treatment-naïve and previously treated settings.
Pharmafile 02/11/2020 06:26
According to a new study, Scotland’s cases of type 2 diabetes has increased by 40% over the last 10 years. Diabetes Scotland's figures show cases rose from 190,772 to 267,615 between 2008 and 2018. They also estimate that 26,347 people are living with the condition. Diabetes Scotland said the figures prove this is now an urgent public health crisis. Angela Mitchel, the Director of the organization, said: “Solving the crisis depends on decisive action led by both the UK and Scottish governments, supported by industry and delivered across our society.

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