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Oral Diseases 10/24/2020 15:39
Abstract. Objectives. This paper aims to study the effect of the active form of vitamin D (calcitriol) on the internalized P. gingivalis in macrophages and to assess the role of autophagy during this process. Materials and Methods. Quantitative RT‐PCR and bacteria culture were used to quantify live P. gingivalis internalized into U937‐derived macrophages.
Oral Diseases 10/24/2020 05:37
Abstract. Objectives. To examine the prognostic significance of pre‐treatment C‐reactive protein (CRP), N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) and cardiac troponin T (cTnT) levels on all‐cause mortality three years after head and neck squamous cell carcinoma (HNSCC) diagnosis. Subjects and Methods. Data from 118 consecutive HNSCC patients, treated between 2012 and 2015, were evaluated prospectively.
Oral Diseases 10/23/2020 12:01
ABSTRACT. Objectives. To determine the differences in psychological states and sleep quality in patients with various Temporomandibular disorder (TMD) subtypes, and to ascertain the relationships between TMD duration with psychological and sleep impairments. Methods. A total of 830 TMD patients were recruited categorized into pain‐related (PT), intra‐articular (IT), and combined (CT) TMD groups.
Oral Diseases 10/20/2020 17:56
Abstract. Objective. The present study summarizes the current knowledge on the role of bacterial extracellular signaling systems, known as quorum sensing (QS), in oral biofilm formation, and on the possibility of blocking these microbial communication systems as a potential approach to prevent and treat oral infectious diseases. Methods. A detailed literature review of the current knowledge of QS in the oral cavity was performed, using the databases MEDLINE (through PubMed) and Web of Science. Results. Accumulating direct and indirect evidence indicates an important role of QS molecules in the oral microbial ecosystem. Conclusions. The mechanisms regulating gene expression through bacterial communication systems constitute a promising target to
Oral Diseases 10/20/2020 17:56
Abstract. Objectives. To investigate whether serum amylase can predict the recovery of salivary volume and determine the correlation of the level of cytokines, including epidermal growth factor, hepatocyte growth factor, and keratinocyte growth factor, with oral mucositis during chemoradiotherapy for oral cancer. Subjects and Methods. This study included 84 patients treated with preoperative chemoradiotherapy followed by curative surgery, following a phase II study protocol.
Oral Diseases 10/20/2020 04:43
Abstract. Objectives. To investigate pathogenic variants of the paired box 9 (PAX9) gene in patients with non‐syndromic oligodontia, and the functional impact of these variants. Subjects and Methods. Whole exome sequencing and Sanger sequencing were utilised to detect gene variants in a cohort of 80 patients diagnosed with non‐syndromic oligodontia.
Oral Diseases 10/19/2020 08:15
The cover image is based on the Original Article Notch activation leads to loss of myoepithelial differentiation and poor outcome in solid adenoid cystic carcinoma by Ye Zhang et al.,
Oral Diseases 10/17/2020 04:34
Abstract. Objective. Whether oral health care during the perioperative period can lead to a better outcome after heart valve surgery has not been adequately elucidated. We examined the effects of perioperative oral care on postoperative inflammation response in patients who underwent heart valve surgery. Materials and Methods. In this retrospective cohort study, 223 patients scheduled for single valve heart surgery were divided into the oral care, who underwent professional teeth cleaning or scaling within 3 days prior to surgery, and also following surgery at least twice a week (n=111), and non‐oral care (n=112) groups. After propensity score‐matching, records of both groups (80:80) were examined after surgery to evaluate inflammation markers.
Oral Diseases 10/14/2020 15:14
Abstract. Objectives. Due to a worldwide increase of drug consumption, oral healthcare professionals are frequently confronted with patients using one or more drugs. A large number of drugs can be accompanied with adverse drug reactions in the orofacial region, amongst others of the tongue. This paper aims to give an overview of drugs that are known to be accompanied with tongue disorders. Materials and methods. The national drug information database for Dutch pharmacists, composed of scientific drug information, guidelines and summaries of product characteristics, was analyzed for drug‐induced tongue disorders. “MedDRA classification” and “Anatomic Therapeutical Chemical codes” were used to categorize the disorders. Results. The database compr.
Oral Diseases 10/14/2020 14:43
ABSTRACT. Objective. Head and neck cancer survivors have increased risk of developing second primary tumors compared to overall population. Because second primary represent a major cause of morbidity and mortality in this population, early detection is fundamental. Materials and methods. In this 10‐years single‐institution study we investigated: incidence, clinical‐pathological risk factors and survival of patients with second primary tumor. We included all patients with diagnosis of squamous cell carcinoma of the head and neck seen at the Modena University Hospital from 2008 to 2018. Results. Among 1177 patients included, 222 (18.9%) developed second primary tumor; its survival probability at 5 years was 40.6%. Alcohol consumption (p=0.0055) a.
Oral Diseases 10/09/2020 11:46
Abstract. Objective. To explore the role of CD10 in cisplatin‐resistance of oral squamous cell carcinoma (OSCC) and its association with the Hedgehog (Hh) signaling pathway and cancer stem cells (CSCs). Methods. The correlation between cell viability and CD10 expression was analyzed in different OSCC cell lines after the cisplatin treatment.

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