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The global struggle against coronavirus disease 2019 (COVID-19) is now in its eighth month since the pandemic virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first emerged. The severe economic, personal, and psychological adverse effects of shutdowns and social distancing make these effective preventive measures challenging to sustain long-term. In 1999, just before the launch of a new millennium, the Centers for Disease Control and Prevention listed vaccines as the most important public health achievement of the 20th century. According to one estimate, more than 42 000 children’s lives are saved annually as a result of the US programs of routine childhood immunizations. Safe and effective COVID-19 vaccines could lead t.
A 31-year-old woman with a history of childhood heart murmur has exercise intolerance due to dyspnea, no chest pain, a fixed split S2 and a 2/6 systolic murmur at the left upper sternal border, and incomplete right bundle-branch block on ECG. Chest imaging shows increased vascularity, cardiomegaly, and an enlarged right atrium and right ventricle. What is the diagnosis and what would you do next?
This Viewpoint discusses the prospects for exacerbation of the coronavirus disease 2019 (COVID-19) pandemic during hurricane season in the US, and proposes reinforcement of public health measures, clear communication, and learning from each experience to reduce the risks of hurricane-related harms and increases in COVID-19 cases.
This Viewpoint proposes legal and policy options for promoting universal face mask wearing in the US and, recognizing the limits of state-by-state implementation, proposes strengthening the authority, independence, and funding of the CDC to enact responses to this and future comparable public health emergencies.
This Viewpoint from the FDA reviews the minimum safety and efficacy standards COVID-19 vaccine candidates would need to meet to be considered for approval, and affirms its commitments to evaluating both in diverse populations and to postmarketing surveillance as means to ensure that approval will meet the highest safety and regulatory standards based on science and evidence, not politics.
This study describes correlations between the dollar amount of relief funding authorized by the US Congress to fund prevention, diagnosis, and treatment of coronavirus disease 2019 (COVID-19) and to reimburse health care entities for lost revenues, and county-level Black population fraction accounting for county COVID-19 burden, comorbidity, and hospital financial health.
In this issue of JAMA, contributors to the World Brain Death Project present an international consensus report on criteria for the diagnosis of brain death, or determination of death by neurologic criteria (BD/DNC). The report addresses inconsistencies in clinical guidelines across different countries and focuses attention on the need for better education and certification of clinicians who are authorized to make this clinical diagnosis.
This Special Communication summarizes consensus recommendations from the World Brain Death project, an international collaborative created to establish minimum standards for diagnosing brain death/death by neurologic criteria (BD/DNC) in children and adults across a broad range of settings and clinical circumstances.
This Viewpoint discusses the role of observational study designs and data in the rapid stand-up of an evidence base for managing the COVID-19 pandemic, proposing ways to position observational research as a foundation for rapid follow-on randomized evaluation without premature overinterpretation of its findings.
To mitigate the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), US states enacted a suite of nonpharmaceutical interventions. School closures were among the most consistently applied of these interventions. Over a 10-day period in March, all 50 US states closed kindergarten-grade 12 schools and childcare centers; nearly all colleges and universities followed suit. These closures were unprecedented in scope, affecting 21 million children in childcare, 57 million students in kindergarten-grade 12, and 20 million college and university students.

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