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In a novel research study conducted by a team from the Neuroregeneration Institute at McLean Hospital, investigators believe they have found key brain cell type changes involving lipids, inflammation, and the development of Parkinson's disease (PD). Their findings appear in the current issue of the Proceedings of the National Academy of Sciences.
October 14, 2020—The temporomandibular joint (TMJ), which forms the back portion of the lower jaw and connects your jaw to your skull, is an anatomically complex and highly loaded structure consisting of cartilage and bone. About 10 million people in the United States alone suffer from TMJ dysfunction due to birth defects, trauma, or disease. Current treatments range from steroid injections that provide only a temporary pain relief, to surgical reconstructions using either prosthetic devices or donor tissue, and often fail to provide long-lasting repair. Researchers have sought a better way to treat TMJ, including investigating biological TMJ grafts grown in the lab that could integrate with the native tissues, remodel the joint over time,
A new study by researchers at the University of Eastern Finland provides novel insight into the previously unknown effects of factors regulating blood vessel formation. In the study, bone morphogenetic factor 6, i.e. BMP6, was shown—for the first time—to regulate blood vessel formation via vascular endothelial growth factor receptor 2 (VEGFR2) and Hippo signaling pathway. The findings can be used in developing treatments for cardiovascular diseases.
The COVID-19 pandemic has led to new rules and expectations for clinical trials. Following guidance from federal agencies, institutions such as UT Southwestern adjusted clinical trial operations. To protect patient safety, changes such as utilizing remote consents, conducting telehealth study visits, and shipping oral study treatment to patients' homes have streamlined the clinical trial participation process.
The first comprehensive study of DNA changes in healthy and diseased human bladder tissue has revealed that 'cancer-driving' mutations are common in healthy bladder tissue. The study, conducted by scientists at the Wellcome Sanger Institute, the University of Cambridge and their collaborators, provides an unprecedented view of the first steps towards bladder cancer.
Organoids are stem cell-based tissue surrogates that can mimic the structure and function of organs, and they have become a key component of numerous types of medical research in recent years. But researchers from The University of Texas at Austin have uncovered problems with the conventional method for growing organoids for common experiments that may cause misleading results.
A trio of researchers, two with the Polish Academy of Sciences, the other the University of Warsaw, has found evidence showing that super-spreader events pushed the exponential growth phase of COVID-19. In their paper published in the journal Royal Society Open Science, Marek Kochańczyk, Frederic Grabowski and Tomasz Lipniacki describe the factors that went into their pandemic computer simulations, and what those simulations revealed.
Patients with BRCA1/2 mutations are at higher risk for breast, ovarian and prostate cancers that can be aggressive when they develop—and, in many cases, resistant to lifesaving drugs. Now scientists at The University of Texas at Austin and Ajou University in South Korea have identified a driver of the drug resistance that can make a life or death difference for patients with these cancers.

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