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Purpose:. Emerging evidence indicates that gut microbiome plays a crucial role in the cancer pathogenesis. Although Fusobacterium nucleatum ( F. nucleatum ) is associated with poor prognosis in multiple cancers, its clinical significance in predicting response to chemotherapy in patients with esophageal squamous cell carcinoma (ESCC) remains unclear. Experimental Design:. The F. nucleatum levels were quantified by qPCR assays in tumor tissues from 551 patients with ESCC from two independent cohorts, including 101 patients who received neoadjuvant chemotherapy prior to curative resection. Associations between F. nucleatum burden and recurrence-free survival (RFS), as well with chemotherapeutic response were evaluated using response evaluation
The immune system is a robust and often untapped accomplice of many standard cancer therapies. A majority of tumors exist in a state of immune tolerance where the patient's immune system has become insensitive to the cancer cells. Because of its lymphodepleting effects, chemotherapy has the potential to break this tolerance. To investigate this, we created a mathematical modeling framework of tumor-immune dynamics. Our results suggest that optimal chemotherapy scheduling must balance two opposing objectives: maximizing tumor reduction while preserving patient immune function. Successful treatment requires therapy to operate in a “Goldilocks Window” where patient immune health is not overly compromised. By keeping therapy “just right,” we sh.
The report provides broad industry data on the Chemotherapy Treatment market, such as size, forecasted growth, profitability, key players, market share and market trends will give you a high-level overview of Chemotherapy Treatment market opportunities.
FeedNavigator (EU) 10/11/2019 08:37
Older age, type of hematologic malignancy (acute leukemia), shorter time from dental extraction to initiation of chemotherapy, low platelet count or hemoglobin level, requirement for red blood cell concentrate or platelet transfusion, and use of an absorbable hemostatic agent were statistically associated with the occurrence of delayed socket healing.
Lancet 10/10/2019 19:17
We thank Xin Yang and colleagues and Sander Bins and Ron Mathijssen for their comments regarding the KEYNOTE-040 study.1 This phase 3 trial showed a clinically meaningful improvement in overall survival1 and stable health-related quality of life2 in patients who received pembrolizumab compared with those who received the standard-of-care treatment.
Lancet 10/10/2019 19:17
These findings contradict the results reported in CheckMate 141, which showed a superiority of nivolumab, another immune checkpoint inhibitor, over chemotherapy in terms of overall survival among patients with p16-positive oropharyngeal cancer (HR 0·56 [95% CI 0·32–0·99]) and no difference in efficacy among patients with p16-negative disease (0·73 [0 ... 10/10/2019 08:47
Condition : Testicular Neoplasms Intervention : Other: Review of Health Information Sponsors : Walter and Eliza Hall Institute of Medical Research; Royal Marsden NHS Foundation Trust; Melbourne Health Active, not recruiting.

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