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Healio News 07/21/2019 08:00
CHICAGO — Bijal D. Shah, MD, associate professor in the department of malignant hematology at Moffitt Cancer Center, spoke with HemOnc Today at ASCO Annual Meeting about the ZUMA-3 study. The phase 1/phase 2 study evaluated KTE-X19 (Kite Pharma), an investigational anti-CD19 chimeric antigen receptor (CAR) T-cell therapy for adults with relapsed/refractory acute lymphoblastic leukemia. Shah provided an overview of end-of-phase-1 results. “We were able to identify a cell dose and a toxicity management algorithm that seems to come with highly encouraging response rates and highly.
ClinicalTrials.gov 07/19/2019 06:50
Activating mutations in the fms like tyrosine kinase 3 (FLT3) gene are observed in approximately 30% of patients with newly diagnosed acute myeloid leukemia (AML.
PubMed News (NIH) 07/19/2019
Status Public on Jul 19, 2019 Title Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection Organism Homo sapiens Experiment type Expression profiling by high throughput sequencing Summary Chemotherapy-resistant cancer recurrence is a major cause of mortality.
PubMed News (NIH) 07/19/2019
Status Public on Jul 19, 2019 Title Downregulation of the histone methyltransferase SETD2 promotes imatinib resistance in chronic myeloid leukemia cells Organism Homo sapiens Experiment type Expression profiling by high throughput sequencing Summary Epigenetic modifiers were important players in the development of hematological malignancies and sensitivity to therapy.

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