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Fight Aging! 08/09/2020 06:11
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents How Calorie Restriction Improves Intestinal Stem Cell Function An Aged Hematopoietic S.
Fight Aging! 08/07/2020 15:22
An interesting study of mouse life span extension via a novel methodology was recently published. The researchers developed a small molecule approach to inhibition of Cdc42, a protein with numerous functions throughout the cell. This is a target for intervention because - at least in cell cultures - loss of Cdc42 activity appears to restore youthful function to aged hematopoietic stem cells. This is the cell population responsible for producing blood and immune cells, and declining immune function with age is driven at least in part by dysfunction in hematopoietic stem cells. Ways to restore immune function in older individuals should prove to be broadly beneficial to health in later life, given that the immune system has roles in tissue ma.
Fight Aging! 08/07/2020 06:29
Mitochondria are the power plants of the cell, the evolved descendants of ancient symbiotic bacteria. They generate the chemical energy store molecules needed to power cellular processes. The herd of hundreds of mitochondria in every cell replicate like bacteria, and carry a small remnant circular genome, the mitochondrial DNA. Mice engineered to lack a functional PolgA gene exhibit defective mitochondrial DNA repair, and as a consequence accumulate mutations in their mitochondrial DNA at a rapid pace. Random mutation and declining mitochondrial function is a feature of aging, and these mitochondrial mutator mice exhibit accelerated aging as a consequence of the more rapid damage they suffer to this vital cell component. Here, researchers e.
Fight Aging! 08/07/2020 06:22
Mitochondria are bacteria-like organelles responsible for producing chemical energy store molecules to power cellular processes. Hundreds of them exist in every cell, constantly undergoing fusion and fission, swapping component parts with one another, and being culled when damaged by the quality control mechanism of mitophagy. Past work has indicated that there is too little mitochondrial fission in old cells, leading to mitochondria that are too large to be effectively removed when damaged. The research here suggests that there is instead too much mitochondrial fission in stem cells, though it is focused specifically on germline stem cells in flies. Mitochondrial dynamics is a balance, and disruption in either direction is problematic. Age.
Fight Aging! 08/06/2020 15:07
Brain-derived neurotrophic factor (BDNF) shows up in many aspects of the interaction between health practices, mechanisms of aging, and mechanisms of neurodegeneration. Most research is focused on the effects of BDNF on neural plasticity, meaning the generation of new neurons from neural stem cell populations, followed by the integration of those new neurons into neural networks, such that they participate in the functioning of the brain. Plasticity is necessary for memory, learning, and maintenance and repair of brain tissue, and in this context the presence of higher levels of BDNF appears to be entirely beneficial. Unfortunately, BDNF levels decline with age, for reasons that are yet to be fully explored. Exercise is known to improve mem.
Fight Aging! 08/06/2020 06:27
In most European countries, electoral rules are such that it is possible to conduct effective advocacy for a cause via a single issue political party. Successful examples include the Green Party and the Pirate Party, but there are many others. In the matter of patient advocacy for investment into rejuvenation research, to treat aging as a medical condition and greatly reduce the suffering that occurs in old age, a number of European advocates have formed single issue political parties to raise awareness. The Party for Health Research in Germany is one such initiative. Here, the European Longevity Initiative is discussed, an alliance of single-issue parties and non-profits across Europe. There is ample need to communicate fresh facts, princi.
Fight Aging! 08/06/2020 06:11
I point out this open access paper not for the content, but for the preamble, in which the author offers a view on why the research community should study aging. Not to learn how it works, but to learn how to intervene in order to make the world a better place, in which people suffer less than is presently the case. This, at root, is why we work on treating aging as a medical condition - because it is by far the greatest source of suffering and death in the world. Aging is characterized by the progressive deterioration of the body's physiological function, which leads to decreased health, increased incidence of degenerative diseases and, finally, a progressive increase in the risk of death. Aging is […]
Fight Aging! 08/05/2020 16:22
In recent years, increasing attention has been given to RNA splicing as a mechanism of interest in aging. RNA splicing is the process of combining intron and exon regions derived from a gene's DNA sequence into the final RNA sequence transcribed from that gene. Introns are usually dropped, exons are usually included, but this process of combination allows multiple proteins to be derived from one gene. Characteristic changes in splicing take place with age, such as alterations in the proportions of different proteins produced from the same gene via different combinations of introns and exons. The regulation of splicing becomes more ragged in general, such as by allowing introns into RNA sequences when they should be excluded, and this is tho.
Fight Aging! 08/05/2020 06:22
In an interesting discovery, researchers here note evidence for the behavior of dopamine generating neurons in the fly brain to have an sizable influence on the pace of aging and longevity in this species. This effect on aging appears to depend on microtubule activity in these cells, but the work leaves open the question of how exactly this change to a very specific population of neurons alters life span. Much more is left to accomplish in order to even begin to speculate on relevance to human biochemistry. Dopaminergic neurons, a critical modulatory system in the brain, are greatly affected by age, but it is unclear whether it can impact the aging process in animals. During the course of studying a putative scaffolding protein, Mask, a […]
Fight Aging! 08/05/2020 06:11
Aging is accompanied by rising levels of sustained inflammation, a chronic overactivation of the immune system. This inappropriate activity on the part of immune cells disrupts tissue function in numerous ways, contributing to onset and progression of all of the common and ultimately fatal age-related conditions, from atherosclerosis to Alzheimer's disease. Ways to control this inflammation without disrupting other, necessary immune functions are thus likely to be broadly beneficial. Numerous age-related changes contribute to chronic inflammation; one of the most relevant for near term intervention is the accumulation of senescent cells in tissues throughout the body. These cells are near all destroyed quite rapidly in youth, with with age
Fight Aging! 08/04/2020 15:48
Today's open access paper outlines an investigation into how the aging of hematopoietic stem cell populations in bone marrow, responsible for producing blood and immune cells, can contribute to age-related dysfunction in the brain. The authors find that detrimental effects are mediated by circulating levels of CyPA, a signaling factor that is a part of the senescence-associated secretory phenotype (SASP), an inflammatory mix of signal molecules produced by senescent cells. The focus here is on direct inhibition of CyPA as an approach to therapy, but senolytic treatments to clear senescent cells may be the more useful approach if these errant cells are indeed the source of raised levels of CyPA. This seems reasonable, but is yet to be proven.
Fight Aging! 08/04/2020 06:22
As a general rule, people care too much about their hair and too little about their blood vessels. One can live without hair. It is interesting to see both (a) just how much work goes into the regeneration of lost hair, and (b) just how little is known of the fine details by which the capacity to grow hair fades with age. It is this lack of knowledge that leads to the present state of uncertain and largely ineffective interventions for hair growth. No-one is entirely sure as to where the root of the problem lies, or where the most effective points of intervention might be. A great deal of exploration takes place, but success is all too much a matter of luck rather than […]
Fight Aging! 08/04/2020 06:12
Presently available methods of determining whether or not amyloid-β aggregates exist in the brain are expensive and invasive. Amyloid-β forms solid deposits in and around cells in the brain for decades prior to the first obvious signs of neurodegeneration, and people with raised levels of these protein aggregates are more likely to progress to dementia. Early, accurate, low-cost measurements of amyloid-β prior to symptoms could lead to the identification of lifestyle choices that minimize risk, as well as to the development of preventative therapies. Absent assays that can achieve this goal, there is little pressure to develop such treatments, however. Thus it is always good news to see progress towards cost-effective ways to measure amyloi.
Fight Aging! 08/03/2020 16:07
The practice of calorie restriction, eating up to 40% fewer calories while still maintaining an optimal intake of micronutrients, is well demonstrated to slow aging and extend healthy life span in near all species and lineages tested to date. It produces sweeping effects on the operation of metabolism - near everything changes, which has made it something of a challenge to identify the principal points of action. Nonetheless, more efficient operation of the cellular housekeeping mechanisms of autophagy is the most plausible mechanism to account for the majority of the benefits. That calorie restriction fails to extend life when autophagy is disabled is the most telling evidence. The open access paper that I'll point out today is illustrativ.
Fight Aging! 08/03/2020 06:22
Trees can adopt a range of strategies not available to animals in order to live for very long periods of time, but they are not immune to mechanisms of aging. That said, those mechanisms are only broadly similar to the biochemistry of aging in animals. It isn't clear that there is anything useful to learn from long-lived plants insofar as human medicine is concerned. Nonetheless, it is an interesting area of study. The oldest trees on Earth have stood for nearly five millennia, and researchers have long wondered to what extent these ancient organisms undergo senescence, physically deteriorating as they age. A recent paper studying ginkgoes, one of the world's longest-lived trees, even found that they may be able to "escape senescence at the.
Fight Aging! 08/03/2020 06:11
Researchers here note a correlation between receiving influenza vaccination, even once, and the later risk of Alzheimer's disease. This is interesting in the context of the present debate over the mechanisms of Alzheimer's, particularly regarding whether or not persistent viral infection is an important driver of the condition. Inflammation and immune system dysfunction are also clearly important in the progression of neurodegenerative conditions. How exactly influenza vaccines might influence this complex decline is an open question. One might hypothesize that this is mediated by something other than biology - that people more likely to take care of their overall health, and thus have a lesser degree of chronic inflammation and lesser inci.
Fight Aging! 08/02/2020 08:56
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents A Genomic Search for Longevity-Associated Genes Points to Iron Metabolism in Human Agi.
Fight Aging! 07/31/2020 14:59
There are two activities in medical science in which both the academic research community and clinical development industry are truly terrible at achieving results, or indeed even at getting started at all. The first is transfer of programs from academia to industry. The renowned valley of death in the development of new medical biotechnologies is very real; so very many programs languish undeveloped simply because neither side can effectively coordinate with the other. The second is the testing of synergies between multiple therapies that are applied at the same time to the same patient for the treatment of the same condition. We live in a world in which age-related conditions are the result of multiple distinct contributing mechanisms, so.
Fight Aging! 07/31/2020 06:11
Fitness produced by training is here shown to correlate with reduced inflammatory signaling, but has no effect on the burden of senescent cells in old muscle tissue. This is interesting, as the accumulation of senescent cells with age is responsible for a sizable fraction of inflammatory signaling in tissues. Senescent cells secrete a potent mix of signals that cause chronic inflammation and tissue dysfunction, and are an important contributing cause of aging. The likely explanation here is that the cellular adaptations to exercise act to reduce harmful aspects of persistent senescent cell signaling. There is a good deal of research to show that senescent cell signaling can be muted to various degrees. This is probably not as a good a strat.

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