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Healio News 06/01/2020 15:30
Adverum Biotechnologies announced the initiation of the phase 2 INFINITY trial to assess a single intravitreal injection of ADVM-022 in patients with diabetic macular edema. The multicenter, randomized, double-masked, active comparator-controlled trial will enroll approximately 33 patients. Researchers will evaluate the time to worsening of DME disease activity in patients who receive an intravitreal injection of ADVM-022 (AAV.7m8-aflibercept) compared with a single aflibercept injection, according to a press release. The INFINITY trial will include three arms. Arm 1 will receive a higher dose.
Healio News 06/01/2020 14:37
Another Ebola outbreak has been confirmed in the Democratic Republic of the Congo, or DRC, as the 2-year long ongoing outbreak in the country goes on. “The government of the Democratic Republic of the Congo announced today that a new outbreak of Ebola Virus Disease has been detected near the city of Mbandaka in Équateur Province,” Tedros Adhanom Ghebreyesus, PhD, MSc, said during a WHO press briefing. “The announcement follows a complex Ebola outbreak in eastern DRC that seems to be in its final phase. The new one is on the other side of the DRC, in Western DRC.”
Healio News 06/01/2020 13:48
Due to the high incidence of complications associated with humeral stem removal, surgeons should familiarize themselves with bone and stem characteristics, as well as safety and extraction techniques, according to a recent presentation. Leesa M. Galatz, MD, professor and chair of the Mount Sinai department of orthopedic surgery, discussed her technique for humeral stem removal and cemented revision at the Current Concepts in Joint Replacement Spring Meeting, which was held as a virtual meeting. “I think it is really important when you are preparing yourself for a revision that you.
Healio News 06/01/2020 13:38
An allogeneic chimeric antigen T-cell therapy plus an anti-CD52 monoclonal antibody appeared safe for certain patients with large B-cell or follicular lymphoma, according to study data presented during the ASCO20 Virtual Scientific Program. The combination therapy also showed clinically relevant antitumor activity, according to the researchers. For allogeneic CAR T-cell therapies to be successful, they must be engineered to reduce the likelihood of graft-versus-host disease, according to Sattva S. Neelapu, MD, professor and deputy chair of the department of lymphoma/myeloma in the division of.
Healio News 06/01/2020 13:16
Early local therapy did not prolong survival among women with de novo metastatic breast cancer and intact primary tumors, according to randomized phase 3 study results presented during the ASCO20 Virtual Scientific Program. Results revealed a 2.5-fold greater risk for local disease progression without locoregional treatment; however, locoregional treatment of the intact primary tumor did not appear associated with improved health-related quality of life. “Based on available data, locoregional treatment for the primary tumor should not be offered to women with stage IV breast cancer with.
Healio News 06/01/2020 12:20
Minority patients, patients with diabetes and older patients showed the most improvement in graft survival in the United States from 1995 to 2017, a study shows. “Short-term and long-term kidney transplant graft survival has been improving over time, but whether this improvement in outcomes is more pronounced in the early (1 year) compared to later periods, and whether it is different among certain patient populations is unknown,” Emilio D. Poggio, MD, of the department of nephrology and hypertension of the Glickman Urological and Kidney Institute at the Cleveland Clinic, and.
Healio News 06/01/2020 12:08
Stopping glaucoma medication resulted in a dose-dependent IOP increase in patients treated for open-angle glaucoma, according to data from two independent clinical trial cohorts. “Despite the continual advent of new laser and surgical procedures, ocular hypotensive eye drops remain the mainstay of initial IOP lowering therapy for most forms of glaucoma,” Thomas V. Johnson, MD, PhD, from the Johns Hopkins Wilmer Eye Institute in Md., and colleagues wrote. “By assuming that the washout IOP is comparable to untreated IOP, we have calculated an inferred IOP reduction induced by.
Healio News 06/01/2020 12:01
The FDA has expanded the approval of ixekizumab injection 80 mg/mL to include treatment of active nonradiographic axial spondyloarthritis in patients with objective signs of inflammation. In a milestone approval, Eli Lilly’s ixekizumab (Taltz) has become the first IL-17A antagonist to be approved by the FDA for nonradiographic axSpA, allowing this drug to treat patients across the entire axSpA spectrum. “We recognize that many patients living with this condition suffer from chronic inflammatory back pain and other symptoms of inflammation for years before being diagnosed, and we’re.
Healio News 06/01/2020 11:47
Results from a trial published in JAMA demonstrated that medication reduction is feasible in older patients receiving multiple hypertensive treatments for BP control. This was the top story in cardiology last week. Another top story was a review of important clinical trials that were presented at the virtual American College of Cardiology Scientific Session, including a large trial that evaluated the nitric oxide pathway in patients with heart failure (HF), a randomized clinical trial comparing rivaroxaban (Xarelto, Bayer/Janssen) plus aspirin vs. placebo plus aspirin in patients with.
Healio News 06/01/2020 11:38
Results showed use of quick response codes for nonsurgical care of pediatric casts after fracture may enhance patient and parent knowledge and prevent unnecessary calls to the treating physician. John Schlechter, DO, FAAOS, and colleagues placed a laminated, waterproof quick response (QR) code on the cast of 50 children with nonsurgically treated fractures. Researchers collected data on cast complications, the number of times the QR code was scanned, who scanned the code, time of day scanned, treatment satisfaction and whether the QR code helped prevent a call to the treating physician. Results.
Healio News 06/01/2020 11:26
Contemporary randomized clinical trials assessing invasive CV interventions are often small with short follow-up and limited power to identify large treatment effects, according to a study published in JAMA Internal Medicine. The study also found that commercially supported trials were linked to differences in results, design and reporting. In particular, commercially supported trials were more likely to report favorable outcomes than other trials, and to report findings inconsistent with the trial results. In this cross-sectional study, Mario F.L. Gaudino, MD, FEBCTS, Stephen and Suzanne Weiss.
Healio News 06/01/2020 11:03
Providing virtual postoperative follow-up for living kidney donors may be an effective alternative to traditional clinic care, according to a poster presented at the virtual American Transplant Congress. “[Living kidney donation] LKD has been declining in the U.S. in recent years, and there is evidence to suggest that this is partly due to the inconvenience of the surgery and follow-up care needed,” Shelby Allen, MD, of the Medical University of South Carolina, and colleagues wrote. “New web-based technology has allowed the development of virtual clinic visits between.
Healio News 06/01/2020 10:35
AstraZeneca announced that ticagrelor has been approved by the FDA to reduce risk for first MI or stroke in high-risk patients with CAD. This marks the first regulatory approval for dual antiplatelet therapy with aspirin plus ticagrelor in patients with high CV risk without a history of MI or stroke, according to a press release from the company. The FDA approval of ticagrelor (Brilinta) was based on findings from the phase 3 THEMIS trial, according the release. As Healio previously reported, ticagrelor added to low-dose aspirin reduced the incidence of ischemic events in patients with stable.
Healio News 06/01/2020 10:06
Despite the often-devastating impact of psoriasis on children, and a variety of unique issues distinguishing these patients from adults, there has, until recently, been a lack of guidelines that specifically cater to juveniles with the disease. No more. Released in November and published in the January issue of Journal of the American Academy of Dermatology, the new guidelines focus for the first time solely on pediatric patients with psoriasis. A joint venture between the American Academy of Dermatology and the National Psoriasis Foundation, they also offer a thorough examination of the.
Healio News 06/01/2020 09:56
During the height of the COVID-19 pandemic in New York, cases requiring surgical repair of acute type A aortic dissection dropped dramatically in the city, according to a new report. The decline may be due to an increase in patients dying at home and/or not wanting to present to the ED because of fear of acquiring COVID-19 at the hospital, the researchers wrote in the Journal of the American College of Cardiology. “From conversations with other aortic surgeons in New York City and posts on social media, we noticed we were all seeing fewer and fewer acute cases, whether aortic dissections.

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