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European Respiratory Journal 06/04/2020 03:05
Multidrug- and rifampicin-resistant tuberculosis (MDR-/RR-TB) have evolved into a global public health crisis. In late 2019, the World Health Organization (WHO) issued a rapid communication [1] advising national TB programmes to phase out the injectable-containing shorter regimen. WHO indicated that the preferred treatment option is a shorter, all-oral, bedaquiline-containing regimen and emphasised that "access to rapid drug susceptibility testing, especially for ruling out fluoroquinolone resistance, is required" before starting the bedaquiline-containing shorter regimen [1].
PubMed News (NIH) 06/04/2020
Contributors : Rachel Lai ; Max Gutierrez ; Tom Lerner Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. Mycobacterium tuberculosis (Mtb) displayed cording phenotypes during intracellular infection. RNA-Seq was used to identify transcriptional programmes expressed by hLEC that actviates pathways relating to cellular pro-survival and cyosolic surveillance of intracellular Mtb. Mtb cording was found to be a mechanism to evade xenophagy in the cytosol of endothelial cells.

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