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Lancet 11/21/2019 19:16
First-line durvalumab plus platinum–etoposide significantly improved overall survival in patients with ES-SCLC versus a clinically relevant control group. Safety findings were consistent with the known safety profiles of all drugs received.
Lancet 11/21/2019 19:16
Tony Mok and colleagues1 report improved overall survival with first-line pembrolizumab immunotherapy over chemotherapy in patients with advanced non-small-cell lung cancer with programmed death ligand 1 tumour proportion score of 1% or greater. The hazard ratio (HR) for the full cohort was 0·81 (95% CI 0·71–0·93; p=0·002) in favour of immunotherapy.1 HR analysis assumes proportional hazards, namely that the ratio of two hazard curves is constant over time. Given the intersecting curves at 8 months, this assumption was clearly not met, severely limiting the clinical interpretability of the reported HR.

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