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Higher red blood cell and platelet counts were associated with an elevated risk of prostate cancer diagnosis, and higher MCV, MCH, MCHC, and MSCV were associated with a lower risk of prostate cancer diagnosis, but red blood cell and platelet parameters were not associated with prostate cancer mortality.
Purpose:. Aggressive variant prostate cancer (AVPC) represents a clinical subset distinguished by therapy resistance and poor prognosis, linked to combined losses of the tumor suppressor genes (TSG) PTEN, RB1 , and TP53 . Circulating tumor cells (CTC) provide a minimally invasive opportunity for identification and molecular characterization of AVPC. We aimed to evaluate the incidence and clinical significance of compound (2+)TSG losses and genomic instability in prostate cancer CTC, and to expand the set genomic biomarkers relevant to AVPC. Experimental Design:. Genomic analysis of chromosomal copy-number alterations (CNA) at single-cell resolution was performed in CTC from patients with and without AVPC before initiating chemotherapy with ca.
PubMed News (NIH) 08/01/2020
Contributors : Brendon M Patierno ; Wen-Chi Foo ; Tyler Allen ; Jason A Somarelli ; Kathryn E Ware ; Santosh Gupta ; Sandra Wise ; John P Wise ; Xiaodi Qin ; Dadong Zhang ; Lingfan Xu ; Yanjing Li ; Xufeng Chen ; Brant A Inman ; Shannon J McCall ; Jiaoti Huang ; Rick A Kittles ; Kouros Owzar ; Simon Gregory ; Andrew J Armstrong ; Daniel J George ; Steven R Patierno ; David S Hsu ; Jennifer A Freedman Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. Here we report the establishment and characterization of a Prostate Cancer Patient Derived Explant (PCPDX) from a patient of West African ancestry with metastatic castration resistant disease.
PubMed News (NIH) 07/29/2020
Contributors : Winnie Wang ; Martin Tenniswood Series Type : Non-coding RNA profiling by array Organism : Homo sapiens ; synthetic construct. Small non-coding RNA profiling of urine exosomal total RNA from patients with or without prostate cancer were performed using Affymetrix GeneChip miRNA 4.0 to identify small non-coding RNA profile that can be used for prostate cancer diagnosis.

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