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Evaluating venetoclax and its potential in treatment-naive acute myeloid leukemia Tristan Knight,1,2 Holly Edwards,3,4 Jeffrey W Taub,1–2,4 Yubin Ge2–41Division of Pediatric Hematology and Oncology, Department of Pediatrics, Children’s Hospital of Michigan, Detroit, MI, USA; 2Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA; 3Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA; 4Molecular Therapeutics Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USAAbstract: Venetoclax (ABT-199), a BH3-mimetic and selective BCL-2 inhibitor, was recently approved by the US Food and Drug Administration (FDA) for the treatment of acute myeloid le.
WN.com 04/22/2019 11:49
CINCINNATI, April 22, 2019 /PRNewswire/ -- Many individuals forced to fight an exceptionally aggressive form of the blood cancer acute myeloid leukemia (AML) don't survive more than five years. The only cure—a bone marrow transplant—often isn't suitable for these very sick patients. Now, an international team of scientists report in Nature Cell Biology on a long-overlooked part of a leukemic cell's internal machinery called the spliceosome, where they found a hyperactive form of a protein called IRAK4 that sends cells on a cancer-causing frenzy. When they targeted the hyperactive form of IRAK4 in laboratory tests to block its function in AML cells, and in patient AML cells transplanted...
WN.com 04/19/2019 04:40
Even moderate consumption of red and processed meat increases bowel cancer risk Processed and red meat hitheadlines this week as our research linked moderate consumption to an increased risk of developing bowel cancer. Our scientists in Oxford found that for every 10,000 people who ate 21g of red and processed meat a day, 40 were diagnosed with bowel cancer. Eating 76g of processed or red meat a day caused 8 extra bowel cancer cases. Follow this Twitter thread for more info. Causes of cancer may leave 'fingerprints' on DNA Scientists in Cambridge say they have catalogued the tell-tale damage that environmental triggers of cancer, like tobacco smoke, leave in cells' DNA. The team told the...

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