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Oncology Central 09/16/2020 04:58
This article reports a real-world US study that aimed to provide an in-depth understanding of treatment patterns, clinical outcomes and patient characteristics in advanced renal cell carcinoma (aRCC). The authors found that over 75% of first-line patients received either tyrosine kinase inhibitor (TKI) monotherapy or immuno-oncology (IO/IO combination therapy) and TKI monotherapy was received by […]. .
Purpose:. Clear cell renal cell carcinoma (ccRCC) is frequently associated with inactivation of the von Hippel–Lindau tumor suppressor, resulting in activation of HIF-1α and HIF-2α. The current paradigm, established using mechanistic cell-based studies, supports a tumor promoting role for HIF-2α, and a tumor suppressor role for HIF-1α. However, few studies have comprehensively examined the clinical relevance of this paradigm. Furthermore, the hypoxia-associated factor (HAF), which regulates the HIFs, has not been comprehensively evaluated in ccRCC. Experimental Design:. To assess the involvement of HAF/HIFs in ccRCC, we analyzed their relationship to tumor grade/stage/outcome using tissue from 380 patients, and validated these associations us.
PubMed News (NIH) 09/12/2020
Contributors : Lidia Moserle ; Susana Aguilar ; Jordi Senserrich ; Oriol Casanovas Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. RNA seq of two independent kidney cancer orthotopic patient-derived xenograft models (RenPDOX-13 & RenPDOX-50) that show differential proinvasive response to antiangiogenics.

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