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PubMed News (NIH) 05/27/2020
Contributors : Dian J Liu ; Xiao J Sun Series Type : Expression profiling by high throughput sequencing Organism : Danio rerio. Setd2 is the only enzyme that catalyzes the activating epigenetic marker, histone H3 lysine 36 trimethylation (H3K36me3), on virtually all actively transcribed protein-coding genes, and this mechanism is evolutionarily conserved from yeast to human.
PubMed News (NIH) 05/27/2020
Contributors : Chenfu Shi ; Helen Ray-Jones ; James Ding ; Kate Duffus ; Yao Fu ; Vasanthi P Gaddi ; Oliver Gough ; Jenny Hankinson ; Paul Martin ; Amanda McGovern ; Annie Yarwood ; Patrick Gaffney ; Steve Eyre ; Magnus Rattray ; Richard B Warren ; Gisela Orozco Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; Other Organism : Homo sapiens. Chromatin looping between regulatory elements and gene promoters presents a potential mechanism whereby disease risk variants affect their target genes.
PubMed News (NIH) 05/27/2020
Contributor : Anthoula Lazaris Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. Colorectal cancer liver metastases (CRCLM) that present with a replacement histopathological growth pattern (HGP) are resistant to neoadjuvant anti-angiogenic therapy.
PubMed News (NIH) 05/27/2020
Contributors : Sophie J Walton ; Han Wang ; Porfirio Quintero-Cadena ; Alex Bateman ; Paul W Sternberg Series Type : Expression profiling by high throughput sequencing Organism : Caenorhabditis elegans. To mitigate the deleterious effects of temperature increases on cellular organization and proteotoxicity, organisms have developed mechanisms to respond to heat stress.
PubMed News (NIH) 05/27/2020
Contributors : Jun-Seok S Lee ; Mamunul M Haque ; Taras Voitsitskyi Series Type : Expression profiling by array Organism : Homo sapiens. Bisphenol S and mono-ethylhexyl phthalate are widely used in the industry of making plastic, mailing envelopes, tickets, etc. Humans are exposed to these compounds by skin contact, inhalation, and food ingestions.
PubMed News (NIH) 05/27/2020
Contributors : Jospeh Saoud ; Marie-Claude Carrier ; Eric Massé ; Sebastien P Faucher Series Type : Expression profiling by array Organism : Legionella pneumophila subsp. pneumophila ; Legionella pneumophila subsp. pneumophila str. Philadelphia 1. Legionella pneumophila (Lp) is a waterborne bacterium able to infect human alveolar macrophages, causing a severe pneumonia known as Legionnaires’ disease. In water, Lp grows inside ciliates and ameoba. Lp is able to survive for several months in water, while searching for host cells. In Lp, the sigma factor RpoS is important for survival in water. Several small regulatory RNAs (sRNA) are known to regulate the expression of RpoS in other bacteria. A previous transcriptomic study showed that RpoS po.
PubMed News (NIH) 05/27/2020
Contributors : Susan M Maxwell ; Tenzin C Lhakhang ; Yael G Kramer ; Yutong Zhang ; Fang Wang ; Adriana Heguy ; Aristotelis Tsirigos ; James A Grifo ; Frederick Licciardi Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. Objective: To determine if embryos diagnosed as mosaic using Next-generation sequencing (NGS) have distinct gene expression profiles compared to embryos diagnosed as euploid or aneuploid.
PubMed News (NIH) 05/27/2020
Contributors : Eric J Devor ; Jesus Gonzalez-Bosquet ; Kristina W Thiel ; Kimberly K Leslie Series Type : Expression profiling by high throughput sequencing ; Genome variation profiling by high throughput sequencing Organism : Homo sapiens. An in-depth examination of five endometrial cancer cell lines in which mutation profiles, copy number variation, micro-satellite instability and homolgous recombination repair ability were determined and assessed in the context of TCGA endometrial cancer groups.
PubMed News (NIH) 05/27/2020
Contributors : Arlo Randall ; Andy Teng ; Xiaowu Liang ; Sukumar Pal ; Alice F Tarantal ; Joseph Fike ; Peter A Barry ; Luis M de la Maza Series Type : Protein profiling by protein array Organism : Chlamydia trachomatis ; Macaca mulatta. To identify immunodominant antigens that elicit a humoral immune response following a primary genital infection, rhesus monkeys were inoculated cervically with Chlamydia trachomatis serovar D. Serum samples were collected and probed with a protein microarray expressing 864/894 (96.4%) of the open reading frames of the C. trachomatis serovar D genome.
PubMed News (NIH) 05/27/2020
Contributors : Pauliina Kallio ; Kari Alitalo Series Type : Expression profiling by high throughput sequencing Organism : Mus musculus. Subcutaneous B16-F0 mouse tumors were treated with anti-Ang2 injections and radiation. 5 days after radiation, tumors were collected and dissociated to obtain single cells and analyzed using the Chromium Single-cell 3'RNA-sequencing system.
PubMed News (NIH) 05/27/2020
Contributors : Wassim Abou-Kheir ; Hisham F Bahmad Series Type : Expression profiling by array Organism : Mus musculus. Orthotopic tumors were previously generated from parental Prostate Luminal (PLum) cells under androgen‑dependent (PLum-AD) and androgen‑independent (PLum-AI) conditions in order to establish cellular models of prostate cancer progression (Abou-Kheir et al., 2011; doi: 10.1371/journal.pone.0026112).


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