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J-Stage 02/14/2020 11:08
Abstract : Macrophage migration inhibitory factor (MIF) has been found to play a central role in controlling the inflammatory response and immune reaction. In this study, we demonstrated the expression of MIF and MIF receptor C-X-C motif chemokine receptor (CXCR) 4 in human acute pulpitis tissue, and that MIF stimulates an inflammatory response in human dental pulp cells. Expression of MIF and CXCR4 in human dental pulp tissue was analyzed by immunohistochemistry. The expression of COX-2 mRNA...
J-Stage 02/14/2020 11:08
Abstract : Dopamine (DA) is a catecholamine and is known as a neurotransmitter. Recent studies have revealed that DA is involved in osteoblastic differentiation. However, the expression of DA during odontoblastic differentiation has not been examined. In this study, we investigated the expression of DA in pulp tissue of rat mandibular incisors and a rat direct capping model by using immunohistochemical analysis. In the study, the expression of DA was detected in pre-odontoblasts and odontobla...
J-Stage 02/05/2020 11:29
Tokushima University Faculty of Dentistry has signed academic agreements with seven faculties in Indonesia, and joint international meetings between these Indonesian universities have been held biannually. Moreover, undergraduate student exchange programs have been executed every year with three faculties. Behind the development of these successful outcomes is a story of a large amount of effort by pioneers. The purpose of this article is to present the process and history of the academic exc...
J-Stage 02/05/2020 10:57
Previously, we have elucidated the role of insulin-like growth factor-I (IGF-I) during the early stages of tooth root formation in mandibular first molars of 5-day-old mice. We reported that IGF-I stimulates the mitotic activity in the outer enamel epithelium of the Hertwig's epithelial root sheath (HERS), resulting in the elongation of the root. In the present study, we used mandibular first molars from 20-day-old mice in order to further elucidate the role of IGF-I during the later stages o...
J-Stage 02/05/2020 10:57
A female outpatient in her 80s suffered sudden vomiting and loss of consciousness in our university dental hospital. Medicine was not given and surgery has not been performed yet. Her Japan Coma Scale levels were in the 3-figure range, her systolic blood pressure had decreased to 90 mmHg, and SpO2 had decreased to 90%. Therefore, the in-hospital medical emergency call system was activated. Cerebral CT scans showed bilateral lacunar infarctions. No neurological findings were observed. The susp...
J-Stage 01/29/2020 11:55
Considering tissue management, partial extraction therapy is an effective tissue preservation procedure. When the tissue is lost, guided bone regeneration can augment the alveolar bone to satisfy the three-dimensional requirements for esthetics. Soft tissue management will inevitably be necessary to maintain regenerated bone and to acquire enough soft tissue volume and quality to be esthetically remodeled with a prosthesis. In addition, soft tissue management can be used to solve the potentia...
J-Stage 01/29/2020 11:40
Dental CT was developed in the late 1990s to enable three-dimensional imaging. Today, it has become an indispensable diagnostic imaging device for dental care, including dental implants. In addition, a wide variety of models have been developed, and it has become possible to select FOV and voxels of various sizes. However, as the exposure dose is about 10 times as high as intraoral radiography and panoramic radiography, attention must be paid to its application. In accordance with the princip...
J-Stage 01/29/2020 11:40
We encountered a case in which blood vessels ran through the area where the bone window would be located in the anterior wall during maxillary sinus floor elevation using a lateral window technique. By performing a preoperative simulation using a bone model created with a 3D printer as part of preoperative planning and using computed tomography (CT) as a form of diagnostic imaging, we were able to detect the position of the blood vessels in advance. This enabled us to gain a comprehensive und...
J-Stage 01/29/2020 11:39
Laws and guidelines relating to ethics are now being issued by the government nearly every year. Not only do dental professionals conducting clinical research have to comply with an increasing number of regulations ; they must first gather a large amount of information to store as knowledge. Since the scope of application of the “Ethics Guidelines for Epidemiological Research” (revised in 2007) and the “Ethical Guidelines for Clinical Research” (revised in 2008)─both issued by the Ministry of...
J-Stage 01/29/2020 11:39
Recently the criteria for success include esthetic satisfaction for patients and practitioners but it is not easy to achieve optimal esthetics in the esthetic zone in cases with multiple implants. This article discusses the conditions for long-term esthetic success. Among such conditions, the first step is setting realistic goals which are shared by both patient and practitioner. If the patient has a high smile, surgical reconstruction of the esthetic soft tissue framework will be necessary a...

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