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Cell Reports 10/16/2020 05:34
The SARS-CoV-2 pandemic has revealed that Africa needs a new public health order to be resilient, adapt, and cope with 21st-century disease threats. The new order will need strengthened continental and national public health institutions; local manufacturing of vaccines, therapeutics, and diagnostics; attraction, training, and retention of a public health workforce; and fostering of respectful local and international partnerships.
Cell Reports 10/16/2020 01:29
PD1/PD-L1-directed immunotherapy, alone or in combination with chemotherapy, dominates the initial treatment of metastatic non-small cell lung cancer. However, our ability to predict who will benefit from these approaches is limited. In this issue of Cell, Nabet et al. report a novel, blood-based methodology to more accurately predict durable disease control with immunotherapy.
Cell Reports 10/15/2020 22:21
In a phase Ib clinical trial, Ott et al. demonstrate feasibility, safety, and immunogenicity of the combination of personalized neoantigen vaccines and PD-1 inhibition in patients with advanced solid tumors. Vaccine-induced T cells persist over time, exhibit cytotoxic potential, and can migrate to tumors. Epitope spread and major pathologic tumor responses were detected following vaccination.
Cell Reports 10/15/2020 17:38
Vaccines save millions of lives from infectious diseases caused by viruses and bacteria. As the world awaits safe and effective COVID-19 vaccines, we celebrate the progresses made and highlight challenges ahead in vaccines and the science behind them.
Cell Reports 10/15/2020 14:25
Tragic events such as pandemics can be remembered as well as foreshadowed by works of art. Paintings by the artists Edvard Munch and John Singer Sargent (1918–19) tell us in real time what it was like to be stricken by the Spanish flu. Paintings by Edward Hopper (1940s and ’50s) foretell the lockdown and social distancing of today’s COVID-19 pandemic.
Cell Reports 10/15/2020 11:14
Infectious diseases killed hundreds of million people, made empires and civilizations vulnerable, and recently took away our freedom to go out, walk, work, travel, meet friends, and visit relatives during the Covid-19 lockdown. Vaccination freed humans from most of infectious diseases of the past. By starting with a virus grown in a cow, vaccination has been propelled by new technologies such as viral growth in eggs and cell culture, chemical conjugation, recombinant DNA, genomics, and synthetic biology. The revolutionary progress in science and technologies increases the confidence that vaccines will continue to provide solutions for the wellbeing of modern society.
Cell Reports 10/15/2020 11:14
The human immunodeficiency virus, the lentivirus that causes AIDS, is responsible for the most prevalent epidemic in the history of mankind. Here in this Timeline, we have attempted to illustrate a short history of HIV-1, from its identification in landmark papers published by Robert Gallo, Myron Essex, and Luc Montagnier, to the numerous drug and vaccine trials as well as the stride toward a possible cure. Even today, a vaccine and cure against HIV-1 remains elusive. In spite of this, in the space of 30 years, from the time when being HIV positive meant an instant death sentence, to today where millions of HIV positive people are living normal lives, the progress we have made in such a short period of time should be celebrated. To view thi.
Cell Reports 10/15/2020 11:14
Masuho et al. quantitatively define G protein selectivity of all of the canonical members of the regulator of G protein signaling (RGS) family. Based on this information, they determine the structural basis of selective RGS-G protein recognition and demonstrate how selectivity determinants evolved. They further show that the RGS-G protein selectivity is affected by the mutational genomic landscape and can be rationally altered.


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