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Healio News 08/23/2019 16:30
Findings published in Pediatrics suggest that a child’s chance of survival in an emergency may depend on the hospital where they receive care. Researchers assessed the pediatric readiness of EDs in five states and found that hospitals with the highest scores had lower mortality rates. “For some time, we’ve known that hospitals vary widely with respect to their readiness to care for pediatric emergencies,” Jeremy M. Kahn, MD, MS, professor of critical care medicine and health policy and management at the University of Pittsburgh, told Infectious Diseases in Children. “What’s.
Healio News 08/23/2019 16:30
Patients with wet age-related macular degeneration who responded well to rAAV.sFLT-1 subretinal gene therapy at 1 year maintained that response through 3 years, but the existence of a biologic efficacy signal was unable to be confirmed. Researchers assessed the safety and 3-year results of rAAV.sFLT-1 gene therapy in combined phase 1 and 2a randomized controlled trials for wet AMD. The trials included 13 patients in a control group and 24 patients in a gene therapy group. All patients received intravitreal ranibizumab 0.5 mg in the study eye at baseline and at a 4-week visit. Patients in the.
Healio News 08/23/2019 14:30
ONL Therapeutics will begin a first-in-human study of its Fas inhibitor for retinal diseases following the completion of $3 million in convertible note financing, according to a press release. ONL1204, a first-in-class small molecule Fas inhibitor, is designed to protect key retinal cells, including photoreceptors, from cell death that occurs in many retinal diseases and conditions and leads to vision loss. ONL is preparing ONL1204 for a phase 1 study in Australia for the treatment of retinal detachment. The company’s management, current investors and new investors participated in the.
Healio News 08/23/2019 14:20
Skin cancer and sun damage procedures, along with laser-, light- and energy-based procedures, have all increased since 2017, according to dermatologist members in the 2018 Survey on Dermatologic Procedures. American Society for Dermatologic Surgery (ASDS) member dermatologists performed more than 12.5 million medically necessary and cosmetic procedures in 2018, an increase of 7.5% from 2017 and a 60% increase since 2012, according to a press release from ASDS. In addition, sun damage treatments were up 63% in just 2 years. Skin cancer treatments have persistently been the most performed.
Healio News 08/23/2019 13:40
The FDA issued a class 2 device recall for the Visibly Online Refraction Test because “the firm has not received authorization from FDA to market the product,” the agency stated. The test is distributed worldwide, including Arizona, California, Delaware, Florida, Illinois, Missouri, Nevada, New York, Ohio, Pennsylvania, Texas, Washington and Utah, according to the FDA’s announcement, dated Aug. 8. The American Optometric Association announced that it issued a formal complaint to the FDA in April 2016 “that emphasized Opternative’s [former name of Visibly] lack of.
Healio News 08/23/2019 13:37
HHS Secretary Alex Azar has proposed a rule that he said would improve substance use disorder treatment and reduce primary care providers’ administrative burden. The proposed changes, if they become law, would impact records that are part of federally assisted substance use disorder treatment programs, commonly known as 42 CFR Part 2. “Part 2 regulations are so complex, that often primary care providers will simply opt not to serve an individual with a substance use disorder in fear that they may unknowingly violate regulations and potentially be held criminally liable,”
Healio News 08/23/2019 13:20
In a post-marketing study, the manufacturer of IBgard showed that over-the-counter peppermint oil treatment effectively managed symptoms of irritable bowel syndrome without the side effect of heartburn. In the Irritable Bowel Syndrome Safety Update at 36 Months (IBSSU36), researchers used a real-world surveillance study and reported on the safety and tolerability profile of IBgard (IM HealthScience). “Such a long and comprehensive post-marketing safety study for a nonprescription product is very rare,” Michael S. Epstein, MD, FACG, AGAF, chief medical advisor for IM HealthScience,
Healio News 08/23/2019 13:08
Among the top stories in gastroenterology last week were the FDA’s revision of draft guidance on the clinical evaluation of gastroparesis drugs and a study that found patients with Crohn’s disease are at higher risk for myocardial infarction than the general population.
Healio News 08/23/2019 12:31
Sustained virologic response after treatment for hepatitis C correlated with a reduced risk for several extrahepatic manifestations including type 2 diabetes, chronic kidney disease, and mood and anxiety disorders. Carmine Rossi, MD, from the British Columbia Center for Disease Control in Vancouver, British Columbia, and colleagues wrote that for infected individuals, the presence of extrahepatic manifestations connected to HCV may be as high as 31%. Further, direct medical costs associated with these complications can range from $72 million to $443 million. “We, along with others, have.
Healio News 08/23/2019 12:30
Anesthesia methods after surgical treatment of distal radial fracture significantly impact early patterns of postoperative pain and opioid consumption equivalents, according to results. However, no difference was seen between anesthesia methods with regard to total opioid equivalent consumption during the first 3 postoperative days and long-term outcomes. Researchers conducted a randomized clinical trial of 88 patients who underwent volar plate fixation for displaced distal radial fractures. There were 44 patients assigned to general anesthesia and 44 patients had regional anesthesia. Total.
Healio News 08/23/2019 11:36
A recently published study found psychiatric illnesses, common among patients with ESKD hospitalized within their first year of dialysis treatment, were associated with higher patient mortality after discharge. “The presence of depression or anxiety is associated with lower quality of life in adult and pediatric kidney disease patients,” Paul L. Kimmel, MD, of the National Institute of Diabetes and Digestive and Kidney Diseases, NIH, and colleagues wrote. “Additionally, depression in adults with ESKD is associated with lower treatment adherence, more frequent hospitalizations.
Healio News 08/23/2019 11:15
Older maternal age was associated with increased risks for severe maternal morbidity and mortality, particularly in those 45 years or older, according to a study pushed in JAMA Network Open. “In many high-income countries, adolescent (age range, 10-19 years) birthrates are declining, whereas there has been a trend toward increasing maternal age,” Kazuyoshi Aoyama, MD, PhD, of the department of anesthesia and pain medicine at the Hospital for Sick Children, the Program in Child Health Evaluative Sciences, Sick Kids Research Institute and the Institute of Health Policy, Management.
Healio News 08/23/2019 11:00
Iconic Therapeutics has signed an agreement with Novartis that will give Novartis an option on Iconic’s ophthalmology program, according to a press release. Iconic is evaluating ICON-4, an anti-tissue factor monoclonal antibody, as a potential therapeutic for age-related macular degeneration, the release said, with clinical trials possibly beginning next year. “Iconic Therapeutics is pursuing an innovative approach to targeting tissue factor, a promising target with early clinical validation and potential applicability in a broad range of diseases, including retinal disease and cancer,”
Healio News 08/23/2019 10:52
Nonalcoholic fatty liver disease fibrosis scores and Fibrosis-4 index scores increased longitudinally and at a higher rate in those with fatty liver and fibrosis stage 2 or higher compared with those with stage 1 or no fibrosis, according to data. “People with NAFLD have increased overall mortality when compared to a matched control population, and the most important predictor of mortality is the extent of liver fibrosis,” Preya J. Patel, BSc, MBBS, MRCP, from the Princess Alexandria Hospital in Brisbane, Australia, and colleagues wrote. “In this study we have shown that.
Healio News 08/23/2019 10:45
Researchers and developers at the Center for Dialysis Innovation at the University of Washington in Seattle, one of the winners in the KidneyX competition, are developing the Ambulatory Kidney to Improve Vitality, an external, wearable, miniaturized dialysis system that the developers hope will be "low-cost, water-efficient, requires minimal anticoagulation, offers complication-free blood access and [be] patient-friendly."


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