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Human medicines European public assessment report (EPAR): Pemetrexed Fresenius Kabi, pemetrexed, Carcinoma, Non-Small-Cell Lung,Mesothelioma, Date of authorisation: 22/07/2016, Revision: 6, Status: Authorised.
Human medicines European public assessment report (EPAR): Taxespira (previously Docetaxel Hospira UK Limited ), docetaxel, Stomach Neoplasms,Prostatic Neoplasms,Breast Neoplasms,Head and Neck Neoplasms,Carcinoma, Non-Small-Cell Lung, Date of authorisation: 28/08/2015, Revision: 8, Status: Withdrawn.
Purpose:. Patients with SCLC rarely undergo biopsies at relapse. When pursued, tissue obtained can be inadequate for molecular testing, posing a challenge in identifying potentially targetable alterations in a clinically meaningful time frame. We examined the feasibility of circulating tumor DNA (ctDNA) testing in identifying potentially targetable alterations in SCLC. Experimental Design:. ctDNA test results were prospectively collected from patients with SCLC between 2014 and 2017 and analyzed. ctDNA profiles of SCLC at diagnosis and relapse were also compared. Results:. A total of 609 samples collected from 564 patients between 2014 and 2017 were analyzed. The median turnaround time for test results was 14 days. Among patients with data on
PubMed News (NIH) 10/15/2019
Contributors : Corina Lorz ; Sara Lázaro ; Miriam Pérez-Crespo ; Jesús M Paramio ; Mirentxu Santos Series Type : Expression profiling by array Organism : Mus musculus. Here we describe novel murine models of High Grade Neuroendocrine Lung Carcinomas driven by the loss of four tumor suppressors: deletion of Rb, PTEN, and p53, in a Rbl1 null background, in a wide variety of lung epithelial cells produces Large Cell Neuroendocrine Carcinoma whereas inactivation of these genes exclusively in basal cells leads to the development of Small Cell Lung Carcinoma, showing that Keratin K5 expressing cells contribute to the development/act as cell of origin of Small Cell Lung Carcinoma differentially influencing the lung cancer type developed.

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